{
  "id": 17548,
  "label": "primary organ-specific lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017207",
  "properties": {
    "xrefs": [
      "GARD:0021064",
      "MEDGEN:1826175",
      "NCIT:C7185",
      "Orphanet:279911",
      "UMLS:C5680788"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    }
  ],
  "children": [
    {
      "id": 4634,
      "label": "primary central nervous system lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4753,
        5530,
        6694,
        17548,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3234",
          "EFO:1000157",
          "GARD:0009318",
          "ICD9:200.5",
          "MEDGEN:79187",
          "MedDRA:10036685",
          "NCIT:C9301",
          "NORD:2002",
          "ONCOTREE:PCNSL",
          "Orphanet:46135",
          "SCTID:307649006",
          "UMLS:C0280803",
          "icd11.foundation:1133193893"
        ],
        "synonyms": [
          "CNS lymphoma",
          "PCNSL",
          "central nervous system lymphoma",
          "lymphoma of central nervous system",
          "malignant lymphomas of CNS",
          "malignant lymphomas of the CNS",
          "microglioma",
          "primary CNS lymphoma",
          "primary brain lymphoma",
          "primary central nervous system lymphoma",
          "primary lymphoma, CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002571"
    },
    {
      "id": 6165,
      "label": "intraocular lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5876,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:775",
          "GARD:0021063",
          "ICD9:200.50",
          "MEDGEN:79344",
          "MESH:D064090",
          "NCIT:C9184",
          "Orphanet:279904",
          "SCTID:420788006",
          "UMLS:C0281658"
        ],
        "synonyms": [
          "PIOL",
          "intraocular lymphoma",
          "primary intraocular lymphoma",
          "primary intraocular non-Hodgkin's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A lymphoma that arises within the eye. Signs and symptoms include decreased vision, uveitis, and vitreous floaters."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004351"
    },
    {
      "id": 17063,
      "label": "primary pulmonary lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018770",
          "MEDGEN:903876",
          "MedDRA:10037418",
          "Orphanet:2420",
          "SCTID:718200007",
          "UMLS:C4273669",
          "icd11.foundation:1042489672"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Primary pulmonary lymphoma (PPL) is a rare lymphoma of the lung, defined as a clonal lymphoid proliferation affecting one or both lungs (parenchyma and/or bronchi) in a patient with no detectable extrapulmonary involvement at diagnosis or during the subsequent 3 months. PPL comprises low grade/indolent B cell PPL forms, the most frequent form represented by the marginal B-cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) and other non-MALT low grade lymphomas; and more rarely high-grade B-cell PPL (including diffuse large B cell lymphoma) and lymphomatoid granulomatosis (LYG)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016570"
    },
    {
      "id": 17547,
      "label": "primary oculocerebral lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5876,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021062",
          "MEDGEN:1814439",
          "Orphanet:279897",
          "UMLS:C5679779",
          "icd11.foundation:446504143"
        ],
        "synonyms": [
          "primary oculocerebral non-Hodgkin lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Primary oculocerebral lymphoma is a rare, primary, organ-specific, extranodal non-Hodgkin's lymphoma (typically diffuse large B-cell lymphoma), simultaneously affecting the intraocular compartments (retina, vitreous, optic nerve, uvea and others) and the central nervous system (commonly the cerebellum, spinal cord or pia mater). The presenting symptoms vary depending on the localization of the tumor and may include vitreous floaters or blurred vision, raised intracranial pressure (headache, vomiting, papilledema) and/or focal neurological deficits."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017205"
    },
    {
      "id": 18035,
      "label": "primary bone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6759",
          "GARD:0021385",
          "MEDGEN:231451",
          "NCIT:C6620",
          "Orphanet:314684",
          "SCTID:766935007",
          "UMLS:C1332582"
        ],
        "synonyms": [
          "bone tissue lymphoma",
          "lymphoma of bone tissue",
          "primary lymphoma of bone",
          "primary lymphoma of the bone",
          "bone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare non-Hodgkin lymphoma or even more rarely, a Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement. The femur, spine, and pelvic bones are the most commonly affected sites. The majority of patients present with bone pain in the affected area. A single bone or multiple skeletal sites may be involved. The prognosis is related to the cell type and the stage of the disease."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017814"
    },
    {
      "id": 18114,
      "label": "primary lymphoma of the conjunctiva",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5378,
        5876,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021426",
          "MEDGEN:1635420",
          "NCIT:C175432",
          "Orphanet:319667",
          "SCTID:763477007",
          "UMLS:C4706485"
        ],
        "synonyms": [
          "conjunctiva lymphoma",
          "conjunctiva primary organ-specific lymphoma",
          "lymphoma of conjunctiva",
          "primary lymphoid conjunctival tumor",
          "primary lymphoid conjunctival tumour",
          "primary organ-specific lymphoma of conjunctiva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Primary lymphoma of the conjunctiva is an extremely rare clonal lymphoid proliferation of the ocular surface, with an indolent course. Clinically it presents with treatment-resistant conjunctivitis, ptosis, excessive tear production or as a painless, salmon-pink, ''fleshy'' patch, with a smooth or multinodular surface, on the bulbar conjunctiva. Histologically it is usually B-cell Non-Hodgkin lymphoma (most often extranodal marginal zone B-cell lymphoma, followed by follicular and diffuse large B-cell lymphoma), with conjunctival T-cell Non-Hodgkin lymphoma being very rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017907"
    },
    {
      "id": 18826,
      "label": "primary cutaneous lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4907,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018698",
          "MEDGEN:220981",
          "MedDRA:10051708",
          "NCIT:C7162",
          "Orphanet:542",
          "SCTID:400001003",
          "UMLS:C1302772"
        ],
        "synonyms": [
          "cutaneous (skin) lymphoma",
          "primary cutaneous lymphoma",
          "primary skin lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cutaneous lymphoma is a heterogeneous entity with respect to its clinical and pathological features, evolutive profile, prognosis, molecular etiology and response to therapy. These specifications have been taken into account in recent classifications, which have placed particular importance on the prognostic implications of these different entities."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018898"
    },
    {
      "id": 19677,
      "label": "thyroid lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4245,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10011",
          "GARD:0019359",
          "MEDGEN:234947",
          "NCIT:C5265",
          "Orphanet:97285",
          "UMLS:C1336753",
          "icd11.foundation:571063415"
        ],
        "synonyms": [
          "lymphoma of the thyroid",
          "lymphoma of the thyroid gland",
          "lymphoma of thyroid",
          "lymphoma of thyroid gland",
          "primary thyroid gland lymphoma",
          "thyroid gland lymphoma",
          "thyroid lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A lymphoma primarily involving the thyroid gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019962"
    }
  ],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    }
  ]
}