{
  "id": 17555,
  "label": "calciphylaxis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017215",
  "properties": {
    "xrefs": [
      "DOID:4734",
      "GARD:0005980",
      "ICD9:275.49",
      "MEDGEN:2404",
      "MESH:D002115",
      "MedDRA:10051714",
      "NCIT:C84607",
      "Orphanet:280062",
      "SCTID:237900002",
      "UMLS:C0006666",
      "icd11.foundation:574291789"
    ],
    "synonyms": [
      "idiopathic calciphylaxis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs. The lack of blood flow (ischemia) damages healthy tissue and causes itto die (necrosis). The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can developand become infected easily. Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more thana few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure. The exact cause of calciphylaxis is unknown. Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4258,
      "label": "calcinosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:182",
          "HP:0003761",
          "ICD9:275.49",
          "MEDGEN:709",
          "MESH:D002114",
          "NCIT:C3672",
          "SCTID:6595006",
          "UMLS:C0006663",
          "icd11.foundation:1374802956"
        ],
        "synonyms": [
          "calcification",
          "calcium deposit(s)",
          "deposit(s), calcium",
          "macrocalcification",
          "pathologic calcification",
          "pathologically calcified structure"
        ],
        "definition": "Deposition of calcium in the tissues. It may be the result of a metabolic disorder or long-standing infection, or it may be associated with the presence of cancer."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002123"
    },
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 17556,
      "label": "calciphylaxis cutis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17555,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021070",
          "MEDGEN:900547",
          "Orphanet:280065",
          "SCTID:717043006",
          "UMLS:C4274083"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Calciphylaxis cutis is a life-threatening syndrome characterized by progressive and painful skin ulcerations associated with media calcification of medium-size and small cutaneous arterial vessels. It affects mainly patients on dialysis or after renal transplantation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017216"
    },
    {
      "id": 17557,
      "label": "visceral calciphylaxis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17555
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021071",
          "MEDGEN:1664968",
          "Orphanet:280068",
          "UMLS:C4749793"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Visceral calciphylaxis is a rare, life-threatening, non-inflammatory vasculopathy disorder characterized by diffuse precipitation of calcium in viscera (mainly in the heart or lungs, but also in the stomach or kidneys) leading to fibrosis and thrombosis, which eventually cause necrotic ulcerations of the tissue. Patients may present with dyspnea, cough and respiratory failure or acute heart block and subsequent sudden cardiac death, depending on the affected organ. The disease mainly affects patients on dialysis or patients having undergone renal transplantation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017217"
    }
  ],
  "roots": [
    {
      "id": 4258,
      "label": "calcinosis"
    },
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}