{
  "id": 17556,
  "label": "calciphylaxis cutis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017216",
  "properties": {
    "xrefs": [
      "GARD:0021070",
      "MEDGEN:900547",
      "Orphanet:280065",
      "SCTID:717043006",
      "UMLS:C4274083"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Calciphylaxis cutis is a life-threatening syndrome characterized by progressive and painful skin ulcerations associated with media calcification of medium-size and small cutaneous arterial vessels. It affects mainly patients on dialysis or after renal transplantation."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17555,
      "label": "calciphylaxis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4258,
        4370,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4734",
          "GARD:0005980",
          "ICD9:275.49",
          "MEDGEN:2404",
          "MESH:D002115",
          "MedDRA:10051714",
          "NCIT:C84607",
          "Orphanet:280062",
          "SCTID:237900002",
          "UMLS:C0006666",
          "icd11.foundation:574291789"
        ],
        "synonyms": [
          "idiopathic calciphylaxis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs. The lack of blood flow (ischemia) damages healthy tissue and causes itto die (necrosis). The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can developand become infected easily. Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more thana few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure. The exact cause of calciphylaxis is unknown. Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017215"
    },
    {
      "id": 19142,
      "label": "skin vascular disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9540",
          "ICD9:709.1",
          "MEDGEN:102473",
          "MESH:D017445",
          "MedDRA:10062171",
          "NCIT:C35254",
          "Orphanet:79379",
          "SCTID:11263005",
          "UMLS:C0162819"
        ],
        "synonyms": [
          "skin vascular disorder",
          "superficial vasculature disease",
          "vascular disease of the skin",
          "vascular skin disease",
          "vasculature skin disease",
          "disorder of blood vessels affecting skin",
          "vascular disorder of skin",
          "vascular disorders of skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease that involves the superficial vasculature."
      },
      "child_count": 40,
      "reference_id": "MONDO:0019293"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17555,
      "label": "calciphylaxis"
    },
    {
      "id": 19142,
      "label": "skin vascular disease"
    }
  ]
}