{
  "id": 17557,
  "label": "visceral calciphylaxis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017217",
  "properties": {
    "xrefs": [
      "GARD:0021071",
      "MEDGEN:1664968",
      "Orphanet:280068",
      "UMLS:C4749793"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Visceral calciphylaxis is a rare, life-threatening, non-inflammatory vasculopathy disorder characterized by diffuse precipitation of calcium in viscera (mainly in the heart or lungs, but also in the stomach or kidneys) leading to fibrosis and thrombosis, which eventually cause necrotic ulcerations of the tissue. Patients may present with dyspnea, cough and respiratory failure or acute heart block and subsequent sudden cardiac death, depending on the affected organ. The disease mainly affects patients on dialysis or patients having undergone renal transplantation."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17555,
      "label": "calciphylaxis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4258,
        4370,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4734",
          "GARD:0005980",
          "ICD9:275.49",
          "MEDGEN:2404",
          "MESH:D002115",
          "MedDRA:10051714",
          "NCIT:C84607",
          "Orphanet:280062",
          "SCTID:237900002",
          "UMLS:C0006666",
          "icd11.foundation:574291789"
        ],
        "synonyms": [
          "idiopathic calciphylaxis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs. The lack of blood flow (ischemia) damages healthy tissue and causes itto die (necrosis). The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can developand become infected easily. Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more thana few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure. The exact cause of calciphylaxis is unknown. Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017215"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17555,
      "label": "calciphylaxis"
    }
  ]
}