{
  "id": 17648,
  "label": "familial vesicoureteral reflux",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017329",
  "properties": {
    "xrefs": [
      "GARD:0017323",
      "MEDGEN:1637583",
      "OMIMPS:193000",
      "Orphanet:289365",
      "SCTID:763716008",
      "UMLS:C4706552"
    ],
    "synonyms": [
      "familial VUR",
      "hereditary vesicoureteral reflux (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Familial vesicoureteral reflux is a rare, non-syndromic urogenital tract malformation characterized by the familial occurrence of retrograde flow of urine from the bladder into the ureter and sometimes the kidneys. Patients may be asymptomatic or may present with recurrent, sometimes febrile, urinary tract infections that, in case of acute pyelonephritis, may lead to serious complications (renal scarring, hypertension, renal failure). Spontaneous resolution of the disorder is possible."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 7598,
      "label": "vesicoureteral reflux",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4098,
        7612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9620",
          "EFO:0007536",
          "HP:0000076",
          "ICD9:593.7",
          "MEDGEN:21852",
          "MESH:D014718",
          "NANDO:2200179",
          "SCTID:197811007",
          "UMLS:C0042580",
          "icd11.foundation:2142055506"
        ],
        "synonyms": [
          "vesicoureteral reflux",
          "vesicoureteral reflux (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Abnormal flow of urine from the urinary bladder back into the ureters."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006007"
    }
  ],
  "children": [
    {
      "id": 9934,
      "label": "vesicoureteral reflux 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018418",
          "MEDGEN:1644868",
          "OMIM:193000",
          "UMLS:C4551858"
        ],
        "synonyms": [
          "VUR1",
          "Vesicoureteral reflux",
          "vesicoureteral reflux 1",
          "VUR"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008653"
    },
    {
      "id": 11895,
      "label": "vesicoureteral reflux, X-linked",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024752",
          "MEDGEN:374134",
          "MESH:C564042",
          "OMIM:314550",
          "UMLS:C1839114"
        ],
        "synonyms": [
          "vesicoureteral reflux, X-linked",
          "VURX"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010755"
    },
    {
      "id": 13620,
      "label": "vesicoureteral reflux 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018419",
          "MEDGEN:370270",
          "MESH:C567053",
          "OMIM:610878",
          "UMLS:C1970483"
        ],
        "synonyms": [
          "ROBO2 vesicoureteral reflux (disease)",
          "vesicoureteral reflux (disease) caused by mutation in ROBO2",
          "vesicoureteral reflux 2",
          "vesicoureteral reflux type 2",
          "VUR2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any vesicoureteral reflux in which the cause of the disease is a mutation in the ROBO2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012573"
    },
    {
      "id": 14389,
      "label": "vesicoureteral reflux 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018420",
          "MEDGEN:462277",
          "OMIM:613674",
          "UMLS:C3150927"
        ],
        "synonyms": [
          "SOX17 vesicoureteral reflux (disease)",
          "vesicoureteral reflux (disease) caused by mutation in SOX17",
          "vesicoureteral reflux 3",
          "vesicoureteral reflux type 3",
          "VUR3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any vesicoureteral reflux in which the cause of the disease is a mutation in the SOX17 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013356"
    },
    {
      "id": 14704,
      "label": "vesicoureteral reflux 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018421",
          "MEDGEN:482069",
          "OMIM:614317",
          "UMLS:C3280439"
        ],
        "synonyms": [
          "VUR4",
          "vesicoureteral reflux 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013682"
    },
    {
      "id": 14705,
      "label": "vesicoureteral reflux 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018422",
          "MEDGEN:482070",
          "OMIM:614318",
          "UMLS:C3280440"
        ],
        "synonyms": [
          "VUR5",
          "vesicoureteral reflux 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013683"
    },
    {
      "id": 14706,
      "label": "vesicoureteral reflux 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018423",
          "MEDGEN:482071",
          "OMIM:614319",
          "UMLS:C3280441"
        ],
        "synonyms": [
          "VUR6",
          "vesicoureteral reflux 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013684"
    },
    {
      "id": 15168,
      "label": "vesicoureteral reflux 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018424",
          "MEDGEN:815667",
          "OMIM:615390",
          "UMLS:C3809337"
        ],
        "synonyms": [
          "VUR7",
          "vesicoureteral reflux 7"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014161"
    },
    {
      "id": 15424,
      "label": "vesicoureteral reflux 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018425",
          "MEDGEN:863268",
          "OMIM:615963",
          "UMLS:C4014831"
        ],
        "synonyms": [
          "TNXB vesicoureteral reflux (disease)",
          "vesicoureteral reflux (disease) caused by mutation in TNXB",
          "vesicoureteral reflux 8",
          "vesicoureteral reflux type 8",
          "VUR8"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any vesicoureteral reflux in which the cause of the disease is a mutation in the TNXB gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014422"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 7598,
      "label": "vesicoureteral reflux"
    }
  ]
}