{
  "id": 17663,
  "label": "Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017346",
  "properties": {
    "xrefs": [
      "GARD:0021150",
      "ICDO:9680/3",
      "MEDGEN:397690",
      "NCIT:C80281",
      "Orphanet:289661",
      "SCTID:716788007",
      "UMLS:C2700007",
      "icd11.foundation:407807101"
    ],
    "synonyms": [
      "EBV Positive diffuse large B-cell lymphoma of the elderly",
      "EBV-Positive diffuse large B-cell lymphoma, NOS",
      "EBV-positive DLBCL of the elderly",
      "Epstein-Barr Virus Positive diffuse large B-cell lymphoma of the elderly",
      "Senile EBV-associated B-cell lymphoproliferative disorder",
      "age-related EBV Positive B-cell lymphoproliferative disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021147",
          "MEDGEN:797800",
          "MedDRA:10068349",
          "Orphanet:289644",
          "UMLS:C2363744"
        ],
        "synonyms": [
          "EBV-associated lymphoproliferative disorder",
          "Epstein-Barr virus-associated malignant lymphoproliferative disorder"
        ],
        "definition": "A range of lymphoproliferative diseases characterized by uncontrolled proliferation of B cells, T cells, or NK cells infected with Epstein-Barr virus. Depending on host immunity and viral factors, viral persistence in host cells can induce lymphoproliferation with a diverse clinical spectrum ranging from simple reactive hyperplasia to aggressive lymphoma/leukemia with unique clinical and pathological presentations."
      },
      "child_count": 11,
      "reference_id": "MONDO:0017343"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma"
    }
  ]
}