{
  "id": 17680,
  "label": "POEMS syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017364",
  "properties": {
    "xrefs": [
      "DOID:14039",
      "EFO:1001115",
      "GARD:0007411",
      "MEDGEN:39276",
      "MESH:D016878",
      "MedDRA:10053869",
      "NANDO:1200033",
      "NCIT:C80303",
      "NORD:1586",
      "Orphanet:2905",
      "SCTID:79268002",
      "UMLS:C0085404",
      "icd11.foundation:1555299114"
    ],
    "synonyms": [
      "Crow-Fukase syndrome",
      "PEP syndrome",
      "POEMS syndrome",
      "Takatsuki syndrome",
      "osteosclerotic myeloma",
      "polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome",
      "polyneuropathy organomegaly",
      "polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6569,
      "label": "leukocyte disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9500",
          "ICD9:288",
          "ICD9:288.9",
          "MEDGEN:7325",
          "MESH:D007960",
          "SCTID:54097007",
          "UMLS:C0023510"
        ],
        "synonyms": [
          "disease of leukocyte",
          "disease or disorder of leukocyte",
          "disorder of leukocyte",
          "disorder, leukocyte",
          "disorders, leukocyte",
          "leukocyte disease",
          "leukocyte disease or disorder",
          "leukocyte disorder",
          "white blood cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving leukocytes."
      },
      "child_count": 46,
      "reference_id": "MONDO:0004805"
    },
    {
      "id": 16613,
      "label": "acquired peripheral neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6950
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842976",
          "Orphanet:182086",
          "UMLS:C5680596"
        ],
        "synonyms": [
          "acquired peripheral neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of peripheral neuropathy that is acquired during the lifetime of the individual."
      },
      "child_count": 12,
      "reference_id": "MONDO:0015923"
    },
    {
      "id": 18348,
      "label": "paraneoplastic neurologic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        20314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007326",
          "ICD9:331.89",
          "MEDGEN:155656",
          "MedDRA:10072106",
          "Orphanet:36388",
          "SCTID:192877007",
          "UMLS:C0751911"
        ],
        "synonyms": [
          "PCD",
          "PNS",
          "nervous system paraneoplastic syndrome",
          "paraneoplastic syndrome of nervous system",
          "paraneoplastic cerebellar degeneration"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A paraneoplastic syndrome that involves the nervous system."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018215"
    },
    {
      "id": 24647,
      "label": "parneoplastic endocrine syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        20314
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the endocrine system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0700252"
    },
    {
      "id": 24648,
      "label": "paraneoplastic hematological syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217,
        20314
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026398"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Paraneoplastic syndrome that involves the hematopoietic system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0700253"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6569,
      "label": "leukocyte disorder"
    },
    {
      "id": 16613,
      "label": "acquired peripheral neuropathy"
    },
    {
      "id": 18348,
      "label": "paraneoplastic neurologic syndrome"
    },
    {
      "id": 24647,
      "label": "parneoplastic endocrine syndrome"
    },
    {
      "id": 24648,
      "label": "paraneoplastic hematological syndrome"
    }
  ]
}