{
  "id": 17704,
  "label": "toxic dermatosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017396",
  "properties": {
    "xrefs": [
      "GARD:0021171",
      "MEDGEN:1842825",
      "Orphanet:293815",
      "UMLS:C5680999"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    }
  ],
  "children": [
    {
      "id": 16203,
      "label": "drug rash with eosinophilia and systemic symptoms",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        7148,
        7238,
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013629",
          "ICD10CM:D72.12",
          "MEDGEN:762193",
          "MESH:D063926",
          "MedDRA:10058919",
          "NCIT:C112208",
          "Orphanet:139402",
          "SCTID:702809001",
          "UMLS:C3541994",
          "icd11.foundation:516577496"
        ],
        "synonyms": [
          "DHS",
          "DRESS",
          "DRESS syndrome",
          "Drug hypersensitivity syndrome",
          "Drug reaction with eosinophilia and Systemic symptoms",
          "dress",
          "drug reaction eosinophilic systemic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015340"
    },
    {
      "id": 17693,
      "label": "acute generalized exanthematous pustulosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4496,
        7238,
        17704,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021164",
          "ICD9:709.8",
          "MEDGEN:209091",
          "MESH:D056150",
          "MedDRA:10048799",
          "NCIT:C112122",
          "Orphanet:293173",
          "SCTID:702617007",
          "UMLS:C0877055"
        ],
        "synonyms": [
          "AGEP",
          "pustular drug eruption",
          "toxic pustuloderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A widespread acute rash characterized by fever and multiple small pustules on a reddish background."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017384"
    },
    {
      "id": 17703,
      "label": "fixed pigmented erythema",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021170",
          "MEDGEN:526203",
          "MedDRA:10048796",
          "Orphanet:293812",
          "SCTID:73692007",
          "UMLS:C0221242",
          "icd11.foundation:20014644"
        ],
        "synonyms": [
          "fixed drug eruption"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017395"
    },
    {
      "id": 19551,
      "label": "toxic epidermal necrolysis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004775",
          "GARD:0007743",
          "ICD9:695.15",
          "MEDGEN:4501",
          "MedDRA:10044223",
          "NANDO:1200246",
          "NANDO:2201007",
          "NCIT:C79777",
          "Orphanet:95455",
          "SCTID:23067006",
          "UMLS:C0014518",
          "icd11.foundation:1575072695",
          "icd11.foundation:195467267"
        ],
        "synonyms": [
          "SJS-TEN",
          "TEN",
          "toxic epidermolysis",
          "Lyell syndrome",
          "Lyell's syndrome",
          "Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Toxic epidermal necrolysis (TEN) is an acute and severe skin disease with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes."
      },
      "child_count": 3,
      "reference_id": "MONDO:0019810"
    },
    {
      "id": 23405,
      "label": "erythema multiforme major",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022049",
          "MEDGEN:469028",
          "NCIT:C3385",
          "Orphanet:502499",
          "UMLS:C3241919"
        ],
        "synonyms": [
          "erythema exsudativum multiforme majus",
          "erythema multiforme majus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A severe, sometimes life-threatening, form of erythema multiforme. It is considered to be a hypersensitivity skin reaction triggered by a variety of stimuli, including infections and medication. It is characterized by raised, edematous papules in the extremities; involvement of one or more mucous membranes; and epidermal detachment involving less than ten percent of the total body surface area."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044719"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    }
  ]
}