{
  "id": 17851,
  "label": "leukocyte adhesion deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017570",
  "properties": {
    "xrefs": [
      "DOID:6612",
      "GARD:0016616",
      "MEDGEN:124419",
      "NANDO:1200355",
      "NANDO:2200755",
      "NCIT:C27874",
      "Orphanet:2968",
      "SCTID:77358003",
      "UMLS:C0272187",
      "icd11.foundation:317341989"
    ],
    "synonyms": [
      "LAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Leukocyte adhesion deficiency (LAD) is a primary immunodeficiency characterized by defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7611,
      "label": "autosomal recessive disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050737",
          "EFO:1000017",
          "ICD9:758.5",
          "MEDGEN:539209",
          "SCTID:85995004",
          "UMLS:C0265388"
        ],
        "synonyms": [
          "autosomal recessive disease or disorder",
          "autosomal recessive hereditary disease",
          "autosomal recessive hereditary disorder",
          "autosomal recessive inherited disease",
          "autosomal recessive inherited disorder",
          "disease or disorder, autosomal recessive",
          "disease, autosomal recessive",
          "recessive hereditary disorder (autosomal)"
        ],
        "definition": "Autosomal recessive form of disease."
      },
      "child_count": 219,
      "reference_id": "MONDO:0006025"
    },
    {
      "id": 16630,
      "label": "functional neutrophil defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020321",
          "MEDGEN:1863601",
          "Orphanet:183681",
          "SCTID:105600002",
          "UMLS:C5924997",
          "icd11.foundation:808756909"
        ],
        "synonyms": [
          "neutrophil disease",
          "neutrophilopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0015978"
    }
  ],
  "children": [
    {
      "id": 8693,
      "label": "leukocyte adhesion deficiency 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17851
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110910",
          "GARD:0006893",
          "MEDGEN:98310",
          "MESH:C535887",
          "NCIT:C4689",
          "OMIM:116920",
          "Orphanet:99842",
          "SCTID:234582006",
          "UMLS:C0398738"
        ],
        "synonyms": [
          "leukocyte adhesion deficiency",
          "ITGB2 leukocyte adhesion deficiency",
          "LAD-I",
          "LAD1",
          "LFA-I deficiency",
          "LFA1 immunodeficiency",
          "lad-I",
          "lad-type I",
          "leukocyte adhesion deficiency 1",
          "leukocyte adhesion deficiency caused by mutation in ITGB2",
          "leukocyte adhesion deficiency type 1",
          "leukocyte adhesion deficiency type I",
          "lymphocyte function-associated antigen 1 immunodeficiency",
          "LFA 1 immunodeficiency",
          "Lad1",
          "Lfa1 immunodeficiency",
          "lad",
          "lad 1",
          "leukocyte adhesion deficiency, type 1",
          "leukocyte adhesion deficiency, type I"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukocyte adhesion deficiency type I (LAD-I) is a form of LAD characterized by life-threatening, recurrent bacterial infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007293"
    },
    {
      "id": 11154,
      "label": "leukocyte adhesion deficiency type II",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7157,
        10564,
        17851,
        17978
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070255",
          "DOID:0080492",
          "GARD:0004634",
          "MEDGEN:96022",
          "MESH:C535755",
          "NCIT:C4690",
          "OMIM:266265",
          "Orphanet:99843",
          "SCTID:234583001",
          "UMLS:C0398739"
        ],
        "synonyms": [
          "CDG IIc",
          "CDG syndrome type IIc",
          "CDG-IIc",
          "CDG2C",
          "CDGIIc",
          "LAD-II",
          "LAD2",
          "RHS",
          "Rambam-Hasharon syndrome",
          "SLC35C1-CDG",
          "lad-II",
          "lad-type II",
          "leukocyte adhesion deficiency type 2",
          "leukocyte adhesion deficiency type II",
          "leukocyte adhesion deficiency, type II",
          "sialyl-Lewis X defect",
          "CDG 2C",
          "SLC35C1-CDG (CDG-IIc)",
          "congenital disorder of glycosylation type IIC",
          "congenital disorder of glycosylation, type IIc",
          "leukocyte adhesion deficiency, type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukocyte adhesion deficiency type II (LAD-II) is a form of LAD characterized by recurrent bacterial infections, severe growth delay and severe intellectual deficit."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009953"
    },
    {
      "id": 14055,
      "label": "leukocyte adhesion deficiency 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17851,
        18939
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110912",
          "GARD:0016915",
          "MEDGEN:411605",
          "MESH:C567555",
          "OMIM:612840",
          "Orphanet:99844",
          "UMLS:C2748536"
        ],
        "synonyms": [
          "FERMT3 leukocyte adhesion deficiency",
          "IADD",
          "LAD-III",
          "LAD1V",
          "LAD3",
          "integrin activation deficiency disease",
          "lad-1 variant",
          "lad-III",
          "leukocyte adhesion deficiency 1 variant",
          "leukocyte adhesion deficiency 3",
          "leukocyte adhesion deficiency caused by mutation in FERMT3",
          "leukocyte adhesion deficiency type 3",
          "leukocyte adhesion deficiency type III",
          "leukocyte adhesion deficiency-1 variant",
          "integrin Activation deficiency disease",
          "leukocyte adhesion deficiency, type 3",
          "leukocyte adhesion deficiency, type III"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Leukocyte adhesion deficiency type III (LAD-III) is a form of LAD characterized by both severe bacterial infections and a severe bleeding disorder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013016"
    }
  ],
  "roots": [
    {
      "id": 7611,
      "label": "autosomal recessive disease"
    },
    {
      "id": 16630,
      "label": "functional neutrophil defect"
    }
  ]
}