{
  "id": 17870,
  "label": "carcinoma of the ampulla of vater",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017590",
  "properties": {
    "xrefs": [
      "DOID:4932",
      "EFO:1000079",
      "GARD:0021237",
      "MEDGEN:120461",
      "MedDRA:10048853",
      "NCIT:C3908",
      "ONCOTREE:AMPCA",
      "Orphanet:300557",
      "SCTID:254609000",
      "UMLS:C0262401",
      "icd11.foundation:267067189"
    ],
    "synonyms": [
      "Ampulloma",
      "ampulla of Vater cancer",
      "ampulla of Vater carcinoma",
      "ampullary cancer",
      "ampullary carcinoma",
      "carcinoma of ampulla of vater",
      "carcinoma of hepatopancreatic ampulla",
      "hepatopancreatic ampulla carcinoma",
      "AMPCA"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3189,
      "label": "ampulla of vater cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3190,
        3191,
        20500
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10020",
          "GARD:0022845",
          "ICD10CM:C24.1",
          "ICD9:156.2",
          "MEDGEN:57785",
          "NCIT:C3536",
          "SCTID:363417006",
          "UMLS:C0153454"
        ],
        "synonyms": [
          "cancer of hepatopancreatic ampulla",
          "hepatopancreatic ampulla cancer",
          "malignant ampulla of Vater neoplasm",
          "malignant ampulla of Vater tumor",
          "malignant ampulla of Vater tumour",
          "malignant hepatopancreatic ampulla neoplasm",
          "malignant neoplasm of ampulla of Vater",
          "malignant neoplasm of hepatopancreatic ampulla",
          "malignant neoplasm of the ampulla of Vater",
          "malignant tumor of ampulla of Vater",
          "malignant tumor of ampulla of vater",
          "malignant tumor of the ampulla of Vater",
          "malignant tumour of the ampulla of Vater"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the ampulla of Vater."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000919"
    },
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7152,
        20500
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4682",
          "GARD:0023363",
          "MEDGEN:116036",
          "NCIT:C3860",
          "SCTID:372101000",
          "UMLS:C0238019"
        ],
        "synonyms": [
          "carcinoma of extrahepatic bile duct",
          "carcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct cancer",
          "extrahepatic bile duct carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the extrahepatic bile duct."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003090"
    },
    {
      "id": 20511,
      "label": "carcinoma of duodenum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3190,
        7176
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025314",
          "MEDGEN:107442",
          "NCIT:C4803",
          "SCTID:254570009",
          "UMLS:C0541912",
          "icd11.foundation:220022932"
        ],
        "synonyms": [
          "cancer of duodenum",
          "cancer of the duodenum",
          "duodenal cancer",
          "carcinoma of duodenum",
          "carcinoma of the duodenum",
          "duodenal carcinoma",
          "duodenum carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that involves the duodenum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021335"
    }
  ],
  "children": [
    {
      "id": 4718,
      "label": "ampulla of vater adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        7742,
        17870
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3502",
          "EFO:0008490",
          "GARD:0023208",
          "MEDGEN:231054",
          "NCIT:C6650",
          "UMLS:C1332243",
          "icd11.foundation:1601321941"
        ],
        "synonyms": [
          "adenocarcinoma of ampulla of Vater",
          "ampulla of Vater adenocarcinoma",
          "ampullary adenocarcinoma",
          "hepatopancreatic ampulla adenocarcinoma",
          "invasive adenocarcinoma of the ampullary region"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the hepatopancreatic ampulla"
      },
      "child_count": 12,
      "reference_id": "MONDO:0002670"
    },
    {
      "id": 5407,
      "label": "ampulla of vater squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7758,
        17870,
        18541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5527",
          "GARD:0023526",
          "MEDGEN:272304",
          "NCIT:C27417",
          "UMLS:C1332251"
        ],
        "synonyms": [
          "ampulla of Vater squamous cell carcinoma",
          "hepatopancreatic ampulla squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003490"
    },
    {
      "id": 5949,
      "label": "ampulla of vater small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        16046,
        17870,
        21453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7136",
          "GARD:0023833",
          "MEDGEN:233974",
          "NCIT:C6655",
          "UMLS:C1332250"
        ],
        "synonyms": [
          "ampulla of Vater small cell NEC",
          "ampulla of Vater small cell carcinoma",
          "ampulla of Vater small cell neuroendocrine carcinoma",
          "ampullary small cell carcinoma",
          "hepatopancreatic ampulla small cell carcinoma",
          "small cell neuroendocrine carcinoma of the ampullary region"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive neuroendocrine carcinoma arising from the ampulla of Vater and the periampullary region. Morphologically, it is characterized by the presence of small malignant cells, necrosis, and a high mitotic rate. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004117"
    }
  ],
  "roots": [
    {
      "id": 3189,
      "label": "ampulla of vater cancer"
    },
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma"
    },
    {
      "id": 20511,
      "label": "carcinoma of duodenum"
    }
  ]
}