{
  "id": 17873,
  "label": "juvenile amyotrophic lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017593",
  "properties": {
    "xrefs": [
      "GARD:0011901",
      "MEDGEN:923704",
      "Orphanet:300605",
      "SCTID:718555006",
      "UMLS:C3468114"
    ],
    "synonyms": [
      "JALS",
      "juvenile Charcot disease",
      "juvenile Lou Gehrig disease",
      "amyotrophic lateral sclerosis, juvenile"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Juvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, and gait disorders with onset before 25 years of age."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6718,
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001356",
          "GARD:0024155",
          "MEDGEN:1642547",
          "OMIMPS:105400",
          "UMLS:C4551993"
        ],
        "synonyms": [
          "hereditary amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005144"
    }
  ],
  "children": [
    {
      "id": 10052,
      "label": "amyotrophic lateral sclerosis type 2, juvenile",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17873,
        23968
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060194",
          "GARD:0015137",
          "MEDGEN:349246",
          "MESH:C565957",
          "OMIM:205100",
          "UMLS:C1859807"
        ],
        "synonyms": [
          "ALS2",
          "ALS2 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 2, juvenile",
          "amyotrophic lateral sclerosis caused by mutation in ALS2",
          "ALS, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ALS2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008780"
    },
    {
      "id": 10053,
      "label": "juvenile amyotrophic lateral sclerosis with dementia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110067",
          "GARD:0024639",
          "MEDGEN:395347",
          "MESH:C565956",
          "OMIM:205200",
          "UMLS:C1859806"
        ],
        "synonyms": [
          "ALS-dementia complex",
          "ALS-dementia Complex",
          "amyotrophic lateral sclerosis, juvenile, with dementia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A juvenile amyotrophic lateral sclerosis that is slowly progressive with concomitantly progressive dementia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008781"
    },
    {
      "id": 12318,
      "label": "amyotrophic lateral sclerosis type 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060197",
          "GARD:0015343",
          "MEDGEN:356388",
          "MESH:C566576",
          "OMIM:602099",
          "UMLS:C1865864"
        ],
        "synonyms": [
          "ALS5",
          "SPG11 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in SPG11",
          "amyotrophic lateral sclerosis 5, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the SPG11 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011196"
    },
    {
      "id": 14736,
      "label": "amyotrophic lateral sclerosis type 16",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060207",
          "GARD:0015794",
          "MEDGEN:482217",
          "OMIM:614373",
          "UMLS:C3280587"
        ],
        "synonyms": [
          "ALS16",
          "SIGMAR1 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in SIGMAR1",
          "amyotrophic lateral sclerosis 16, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the SIGMAR1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013715"
    }
  ],
  "roots": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis"
    }
  ]
}