{
  "id": 17874,
  "label": "indolent B-cell non-Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017594",
  "properties": {
    "xrefs": [
      "GARD:0021244",
      "MEDGEN:1741600",
      "NCIT:C171299",
      "Orphanet:300842",
      "UMLS:C5419078"
    ],
    "synonyms": [
      "indolent B-cell NHL",
      "B cell lymphoma, indolent",
      "indolent B cell lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001938",
          "GARD:0020132",
          "NANDO:2200020",
          "NCIT:C3457",
          "Orphanet:171915"
        ],
        "synonyms": [
          "B-cell NHL",
          "B-cell lymphoma",
          "B-cell non Hodgkin's lymphoma",
          "B-cell non-Hodgkin lymphoma",
          "B-cell non-Hodgkin's lymphoma",
          "lymphomas non-Hodgkin's B-cell",
          "non-Hodgkin's B-cell lymphoma",
          "non-Hodgkin's lymphoma B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"
      },
      "child_count": 10,
      "reference_id": "MONDO:0015759"
    }
  ],
  "children": [
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6694,
        6710,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1040",
          "EFO:0000095",
          "GARD:0006104",
          "ICD10CM:C91.1",
          "ICD9:204.1",
          "MEDGEN:44120",
          "MESH:D015451",
          "MedDRA:10008958",
          "NCIT:C3163",
          "NORD:971",
          "OMIM:151400",
          "Orphanet:67038",
          "UMLS:C0023434"
        ],
        "synonyms": [
          "B cell CLL",
          "B cell chronic lymphocytic leukaemia",
          "B cell chronic lymphocytic leukemia",
          "B cell lymphocytic leukaemia",
          "B cell lymphocytic leukemia",
          "B-CLL",
          "B-cell CLL",
          "B-cell chronic lymphocytic leukemia",
          "B-cell chronic lymphogenous leukaemia",
          "B-cell chronic lymphogenous leukemia",
          "B-cell chronic lymphoid leukaemia",
          "B-cell chronic lymphoid leukemia",
          "B-cell lymphocytic leukaemia",
          "B-cell lymphocytic leukemia",
          "BCLL",
          "CLL",
          "Chronic Lymphocytic Leukemia",
          "chronic B-cell lymphocytic leukaemia",
          "chronic B-cell lymphocytic leukemia",
          "chronic lymphatic leukemia",
          "chronic lymphocytic leukaemia (CLL)",
          "chronic lymphocytic leukemia",
          "chronic lymphocytic leukemia (CLL)",
          "chronic lymphogenous leukaemia",
          "chronic lymphogenous leukemia",
          "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
          "hematopoeitic - chronic lymphocytic leukemia (CLL)",
          "lymphoplasmacytic leukemia",
          "leukemia, chronic LYMPHOCYTIC",
          "leukemia, chronic lymphatic",
          "leukemia, lymphocytic, chronic",
          "small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004948"
    },
    {
      "id": 16569,
      "label": "indolent primary cutaneous B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        16570,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020164",
          "MEDGEN:1843003",
          "Orphanet:178557",
          "UMLS:C5680499"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0015819"
    },
    {
      "id": 17884,
      "label": "marginal zone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17874,
        22946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050748",
          "EFO:1000630",
          "GARD:0013237",
          "ICDO:9699/3",
          "MEDGEN:277950",
          "NCIT:C4341",
          "ONCOTREE:MZL",
          "Orphanet:300912",
          "SCTID:447100004",
          "UMLS:C1367654"
        ],
        "synonyms": [
          "MZBCL",
          "MZL",
          "lymphoma of marginal zone B cell",
          "marginal zone B cell lymphoma",
          "marginal zone B-cell lymphoma",
          "marginal zone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0017604"
    },
    {
      "id": 18620,
      "label": "lymphoplasmacytic lymphoma without IgM production",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021851",
          "MEDGEN:1814446",
          "Orphanet:443159",
          "UMLS:C5680061"
        ],
        "synonyms": [
          "lymphoplasmacytic lymphoma without Immunoglobulin M production"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018621"
    },
    {
      "id": 18834,
      "label": "follicular lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6694,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050873",
          "GARD:0002356",
          "HGNC:990",
          "ICD10CM:C82",
          "ICD10WHO:C82",
          "ICDO:9690/3",
          "MEDGEN:7417",
          "MESH:D008224",
          "NCIT:C3209",
          "NORD:1983",
          "ONCOTREE:FL",
          "Orphanet:545",
          "SCTID:308121000",
          "UMLS:C0024301",
          "icd11.foundation:797822185"
        ],
        "synonyms": [
          "follicle center lymphoma",
          "follicle centre lymphoma",
          "follicular center cell lymphoma",
          "follicular centre cell lymphoma",
          "follicular non-Hodgkin lymphoma",
          "follicular non-Hodgkin's lymphoma",
          "lymphoma, follicular center cell",
          "lymphoma, follicular centre cell",
          "lymphoma, follicular, malignant",
          "lymphoma, follicular"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018906"
    },
    {
      "id": 24018,
      "label": "Waldenstrom macroglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2907,
        17874,
        18954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060901",
          "EFO:0009441",
          "GARD:0007872",
          "ICD10CM:C88.0",
          "MEDGEN:6174",
          "MESH:D008258",
          "MedDRA:10047801",
          "NCIT:C80307",
          "NORD:1834",
          "OMIMPS:153600",
          "ONCOTREE:WM",
          "Orphanet:33226",
          "UMLS:C0024419"
        ],
        "synonyms": [
          "Waldenstrom macroglobulinemia",
          "Waldenstrom's macroglobulinemia",
          "Waldenström Macroglobulinemia",
          "Waldenström macroglobulinemia",
          "Waldenstroem's macroglobulinemia",
          "Waldenstrom's macroglobulinaemia",
          "Waldenstrom's syndrome",
          "macroglobulinemia of Waldenstrom"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0100280"
    }
  ],
  "roots": [
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma"
    }
  ]
}