{
  "id": 17875,
  "label": "aggressive B-cell non-Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017595",
  "properties": {
    "xrefs": [
      "GARD:0021245",
      "MEDGEN:1791561",
      "NCIT:C178541",
      "Orphanet:300846",
      "UMLS:C5555120"
    ],
    "synonyms": [
      "aggressive B-cell NHL"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001938",
          "GARD:0020132",
          "NANDO:2200020",
          "NCIT:C3457",
          "Orphanet:171915"
        ],
        "synonyms": [
          "B-cell NHL",
          "B-cell lymphoma",
          "B-cell non Hodgkin's lymphoma",
          "B-cell non-Hodgkin lymphoma",
          "B-cell non-Hodgkin's lymphoma",
          "lymphomas non-Hodgkin's B-cell",
          "non-Hodgkin's B-cell lymphoma",
          "non-Hodgkin's lymphoma B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"
      },
      "child_count": 10,
      "reference_id": "MONDO:0015759"
    }
  ],
  "children": [
    {
      "id": 8648,
      "label": "Burkitt lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6694,
        17660,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8584",
          "EFO:0000309",
          "GARD:0005973",
          "ICD10CM:C83.7",
          "ICD9:200.2",
          "ICDO:9687/3",
          "MEDGEN:2377",
          "MESH:D002051",
          "MedDRA:10006595",
          "MedDRA:10053518",
          "MedDRA:10067184",
          "NCIT:C2912",
          "OMIM:113970",
          "ONCOTREE:BL",
          "Orphanet:543",
          "SCTID:118617000",
          "UMLS:C0006413",
          "icd11.foundation:2100138081"
        ],
        "synonyms": [
          "Burkitt lymphoma",
          "Burkitt lymphoma/leukemia",
          "Burkitt's lymphoma",
          "Burkitt's tumour",
          "Burkitt's tumour or lymphoma",
          "burkitt lymphoma, somatic",
          "small non-cleaved cell lymphoma",
          "small non-cleaved cell lymphoma, Burkitt's type",
          "BL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare form of malignant mature B-cell non-Hodgkin lymphoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0007243"
    },
    {
      "id": 18757,
      "label": "high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021980",
          "MEDGEN:1617477",
          "Orphanet:480541",
          "UMLS:C4524190"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018813"
    },
    {
      "id": 18808,
      "label": "mantle cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050746",
          "EFO:1001469",
          "GARD:0006969",
          "ICD10CM:C83.1",
          "ICD9:200.40",
          "ICDO:9673/3",
          "MEDGEN:1668377",
          "MESH:D020522",
          "MedDRA:10061275",
          "NCIT:C4337",
          "NORD:1399",
          "ONCOTREE:MCL",
          "Orphanet:52416",
          "SCTID:443487006",
          "UMLS:C4721414",
          "icd11.foundation:1804127841"
        ],
        "synonyms": [
          "LCM",
          "MCL",
          "classical mantle cell lymphoma",
          "mantle cell lymphoma",
          "mantle zone lymphoma",
          "lymphoma, mantle cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018876"
    },
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    },
    {
      "id": 19286,
      "label": "B-cell prolymphocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3282,
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081041",
          "EFO:1000102",
          "GARD:0008223",
          "ICDO:9833/3",
          "MEDGEN:105396",
          "MESH:D054403",
          "NCIT:C4753",
          "ONCOTREE:BPLL",
          "Orphanet:86852",
          "SCTID:277619001",
          "UMLS:C0475801",
          "icd11.foundation:1997215876"
        ],
        "synonyms": [
          "B prolymphocytic leukaemia",
          "B prolymphocytic leukemia",
          "B-PLL",
          "B-cell prolymphocytic leukemia",
          "BPLL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019461"
    },
    {
      "id": 19962,
      "label": "precursor B-cell acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080638",
          "GARD:0016920",
          "ICDO:9836/3",
          "MEDGEN:83896",
          "NANDO:2200001",
          "NANDO:2200022",
          "NCIT:C8644",
          "Orphanet:99860",
          "UMLS:C0349636",
          "icd11.foundation:1099674056"
        ],
        "synonyms": [
          "B acute lymphoblastic leukaemia",
          "B acute lymphoblastic leukemia",
          "B cell acute lymphocytic leukaemia",
          "B cell acute lymphocytic leukemia",
          "B-ALL",
          "B-cell acute lymphoblastic leukaemia",
          "B-cell acute lymphoblastic leukemia",
          "B-cell acute lymphocytic leukaemia",
          "B-cell acute lymphocytic leukemia",
          "B-cell lymphoblastic leukaemia",
          "B-cell lymphoblastic leukemia",
          "B-cell type acute leukaemia",
          "B-cell type acute leukemia",
          "acute B cell lymphocytic leukaemia",
          "acute B cell lymphocytic leukemia",
          "acute B-cell lymphocytic leukaemia",
          "acute B-cell lymphocytic leukemia",
          "B cell precursor type acute leukaemia",
          "B cell precursor type acute leukemia",
          "B-cell precursor type acute leukaemia",
          "B-cell precursor type acute leukemia",
          "B-precursor ALL",
          "precursor B-cell acute lymphoblastic leukemia/lymphoma",
          "precursor B-cell acute lymphocytic leukaemia",
          "precursor B-cell acute lymphocytic leukemia",
          "precursor B-cell acute lymphocytic leukemia/lymphoma",
          "precursor B-lymphoblastic leukaemia",
          "precursor B-lymphoblastic leukaemia (B-precursor ALL)",
          "precursor B-lymphoblastic leukemia",
          "precursor B-lymphoblastic leukemia (B-precursor ALL)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most frequent type of acute lymphoblastic leukemia. Approximately 75% of cases occur in children under six years of age. This is a good prognosis leukemia. In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%. Approximately 80% of children appear to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, 2001)"
      },
      "child_count": 4,
      "reference_id": "MONDO:0020511"
    }
  ],
  "roots": [
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma"
    }
  ]
}