{
  "id": 17878,
  "label": "primary cutaneous anaplastic large cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017598",
  "properties": {
    "xrefs": [
      "GARD:0021247",
      "MEDGEN:266255",
      "MESH:D054446",
      "MedDRA:10065863",
      "NCIT:C6860",
      "ONCOTREE:PCALCL",
      "Orphanet:300865",
      "UMLS:C1301362",
      "icd11.foundation:1972636482"
    ],
    "synonyms": [
      "ALCL, cutaneous",
      "C-ALCL",
      "anaplastic large-cell lymphoma, primary cutaneous type",
      "primary C-ALCL",
      "primary anaplastic large cell lymphoma of skin",
      "primary anaplastic large cell lymphoma of the skin",
      "primary cutaneous CD30 Positive anaplastic large cell lymphoma",
      "primary cutaneous CD30+ ALCL",
      "primary cutaneous CD30+ anaplastic large cell lymphoma",
      "regressive atypical histiocytosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare T-cell non-Hodgkin lymphoma that affects the skin and generally shows no extracutaneous involvement at presentation. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders along with lymphomatoid papulosis with which it shares overlapping clinical and histopathologic features."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3019,
      "label": "primary cutaneous T-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18826
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060061",
          "EFO:0002913",
          "GARD:0022811",
          "ICDO:9709/3",
          "MESH:D016410",
          "NCIT:C3467"
        ],
        "synonyms": [
          "CTCL",
          "PCTCL",
          "T-cell non-Hodgkin's lymphoma of skin",
          "T-cell non-Hodgkin's lymphoma of the skin",
          "cutaneous T cell lymphoma",
          "cutaneous T-cell lymphoma",
          "cutaneous T-cell non-Hodgkin lymphoma",
          "cutaneous T-cell non-Hodgkin's lymphoma",
          "primary cutaneous T-cell non-Hodgkin lymphoma",
          "primary cutaneous T-cell non-Hodgkin's lymphoma",
          "skin T-cell non-Hodgkin's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0000607"
    },
    {
      "id": 18825,
      "label": "primary cutaneous CD30+ T-cell lymphoproliferative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018697",
          "MEDGEN:1843249",
          "MedDRA:10065863",
          "NCIT:C7195",
          "Orphanet:541",
          "UMLS:C5679826",
          "icd11.foundation:1046496266"
        ],
        "synonyms": [
          "primary cutaneous Ki-1+ T-cell lymphoproliferative disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018897"
    },
    {
      "id": 19798,
      "label": "anaplastic large cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050744",
          "EFO:0003032",
          "GARD:0003112",
          "HGNC:427",
          "ICD9:200.6",
          "ICD9:200.60",
          "ICDO:9714/3",
          "MEDGEN:61533",
          "MESH:D017728",
          "NANDO:2200021",
          "NCIT:C3720",
          "ONCOTREE:ALCL",
          "Orphanet:98841",
          "SCTID:277637000",
          "UMLS:C0206180"
        ],
        "synonyms": [
          "ALCL",
          "CD30 Positive anaplastic large cell lymphoma",
          "CD30 positive anaplastic large cell lymphoma",
          "Ki-1 lymphoma",
          "Ki-1 positive anaplastic large cell lymphoma",
          "Ki-1+ ALCL",
          "Ki-1+ anaplastic large cell lymphoma",
          "anaplastic large cell lymphoma",
          "primary systemic ALCL",
          "sACL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL."
      },
      "child_count": 5,
      "reference_id": "MONDO:0020325"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:231373",
          "NCIT:C36025",
          "UMLS:C1332287"
        ],
        "synonyms": [
          "anaplastic malignant neoplasm"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020633"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3019,
      "label": "primary cutaneous T-cell non-Hodgkin lymphoma"
    },
    {
      "id": 18825,
      "label": "primary cutaneous CD30+ T-cell lymphoproliferative disease"
    },
    {
      "id": 19798,
      "label": "anaplastic large cell lymphoma"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer"
    }
  ]
}