{
  "id": 17879,
  "label": "splenic diffuse red pulp small B-cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017599",
  "properties": {
    "xrefs": [
      "GARD:0021248",
      "ICDO:9591/3",
      "MEDGEN:397437",
      "NCIT:C80309",
      "ONCOTREE:SDRPL",
      "Orphanet:300869",
      "SCTID:763884007",
      "UMLS:C2699508",
      "icd11.foundation:1970934986"
    ],
    "synonyms": [
      "SDRPL",
      "splenic diffuse red pulp lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Splenic diffuse red pulp small B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal proliferation of small, monomorphous, basophilic B-lymphocytes, with villous cytoplasm, in the splenic red pulp, bone marrow and peripheral blood. It typically presents in the late clinical stages with splenomegaly and moderate lymphocytosis. Cytopenias are rare and likely associated with hypersplenism."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17884,
      "label": "marginal zone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17874,
        22946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050748",
          "EFO:1000630",
          "GARD:0013237",
          "ICDO:9699/3",
          "MEDGEN:277950",
          "NCIT:C4341",
          "ONCOTREE:MZL",
          "Orphanet:300912",
          "SCTID:447100004",
          "UMLS:C1367654"
        ],
        "synonyms": [
          "MZBCL",
          "MZL",
          "lymphoma of marginal zone B cell",
          "marginal zone B cell lymphoma",
          "marginal zone B-cell lymphoma",
          "marginal zone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0017604"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17884,
      "label": "marginal zone lymphoma"
    }
  ]
}