{
  "id": 18013,
  "label": "gastric adenocarcinoma and proximal polyposis of the stomach",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017790",
  "properties": {
    "xrefs": [
      "GARD:0017416",
      "MEDGEN:1657285",
      "NCIT:C172989",
      "OMIM:619182",
      "Orphanet:314022",
      "UMLS:C4749917"
    ],
    "synonyms": [
      "APC-related gastric adenocarcinoma and proximal polyposis of the stomach",
      "GAPPS",
      "familial fundic gland polyposis with gastric cancer",
      "fundic gland polyposis",
      "polyposis, gastric",
      "polyposis, gastric, Dos Santos and de Magalhaes 1980"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An autosomal dominant disorder caused by specific pathogenic variants in the APC gene promoter, characterized by proximal gastric polyposis and an increased risk of gastric adenocarcinoma."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2742,
      "label": "polyposis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20316
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:137722",
          "NANDO:2100257",
          "NCIT:C4089",
          "UMLS:C0334108"
        ],
        "synonyms": [
          "multiple polyps",
          "polyposis"
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0000147"
    },
    {
      "id": 2903,
      "label": "autosomal dominant disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050736",
          "ICD9:758.5",
          "MEDGEN:539206",
          "SCTID:11164009",
          "UMLS:C0265385"
        ],
        "synonyms": [
          "autosomal dominant disease or disorder",
          "autosomal dominant hereditary disorder",
          "autosomal dominant inherited disorder",
          "disease or disorder, autosomal dominant",
          "disease, autosomal dominant"
        ],
        "definition": "Autosomal dominant form of disease."
      },
      "child_count": 192,
      "reference_id": "MONDO:0000426"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021758",
          "MEDGEN:1843054",
          "Orphanet:423776",
          "UMLS:C5680075"
        ],
        "synonyms": [
          "hereditary cancer of stomach",
          "hereditary gastric cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Hereditary gastric cancer refers to the occurrence of gastric cancer in a familial context and is described as two or more cases of gastric cancer in first or second degree relatives with at least one case diagnosed before the age of 50. Familial clustering is observed in 10% of all cases of gastric cancer, and includes hereditary diffuse gastric cancer (early onset diffuse-type gastric cancer), gastric adenocarcinoma and proximal polyposis of the stomach and familial intestinal gastric cancer (familial clustering of intestinal type gastric adenocarcinoma). Hereditary gastric cancer can also occur in other hereditary cancer syndromes such as Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis and juvenile polyposis syndrome."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018502"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2742,
      "label": "polyposis"
    },
    {
      "id": 2903,
      "label": "autosomal dominant disease"
    },
    {
      "id": 18536,
      "label": "hereditary gastric cancer"
    }
  ]
}