{
  "id": 18018,
  "label": "ameloblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017795",
  "properties": {
    "xrefs": [
      "DOID:0050894",
      "GARD:0005747",
      "ICDO:9310/0",
      "MEDGEN:1457",
      "MESH:D000564",
      "MedDRA:10066796",
      "NCIT:C4313",
      "NORD:764",
      "Orphanet:314419",
      "SCTID:285311001",
      "UMLS:C0002448"
    ],
    "synonyms": [
      "ameloblastoma",
      "ameloblastoma of jaw",
      "Adenoameloblastoma",
      "adamantinoma",
      "adenomatoid odontogenic tumor",
      "adenomatoid odontogenic tumour",
      "aot"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "The most common odontogenic tumor, arising from the epithelial component of the embryonic tooth and usually affecting the molar-ramus region of the mandible or maxilla. Although most ameloblastomas are morphologically and clinically benign, they may cause extensive local destruction, recur, or metastasize."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 3040,
      "label": "musculoskeletal system benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4222,
        6887
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060099",
          "MEDGEN:1709701",
          "NCIT:C166356",
          "UMLS:C5237920"
        ],
        "synonyms": [
          "musculoskeletal system benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the musculoskeletal system."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000636"
    },
    {
      "id": 20417,
      "label": "odontogenic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7231,
        8422,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027878",
          "ICDO:9270/1",
          "MEDGEN:10426",
          "MESH:D009808",
          "NCIT:C3286",
          "UMLS:C0028880"
        ],
        "synonyms": [
          "calcareous tooth neoplasm",
          "calcareous tooth neoplasm (disease)",
          "calcareous tooth tumor",
          "calcareous tooth tumour",
          "neoplasm of calcareous tooth",
          "odontogenic neoplasm",
          "odontogenic tumor",
          "odontogenic tumour",
          "tumor of calcareous tooth",
          "tumour of calcareous tooth"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing and are not associated with specific clinical symptoms. Pain is absent or slight. Malignant tumors are usually associated with rapid swelling and pain."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021192"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/0",
          "ICDO:8011/0",
          "MEDGEN:90747",
          "NCIT:C4092",
          "UMLS:C0334232"
        ],
        "synonyms": [
          "benign epithelial neoplasm",
          "benign epithelial tumor",
          "benign epithelial tumour",
          "benign epithelioma",
          "benign neoplasm of epithelium",
          "benign neoplasm of the epithelium",
          "benign tumor of epithelium",
          "benign tumor of the epithelium",
          "benign tumour of epithelium",
          "benign tumour of the epithelium",
          "epithelial neoplasm, benign",
          "epithelioma, benign"
        ],
        "definition": "A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites."
      },
      "child_count": 50,
      "reference_id": "MONDO:0036976"
    }
  ],
  "children": [
    {
      "id": 2964,
      "label": "bone ameloblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3036,
        18018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050895",
          "GARD:0022782"
        ],
        "synonyms": [
          "ameloblastoma of bone tissue",
          "bone tissue ameloblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A ameloblastoma that involves the bone tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000513"
    },
    {
      "id": 7736,
      "label": "desmoplastic ameloblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000215",
          "GARD:0024321",
          "MEDGEN:105345",
          "NCIT:C39758",
          "UMLS:C0457533"
        ],
        "synonyms": [
          "desmoplastic ameloblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An ameloblastoma with prominent desmoplastic stroma that causes compression of the neoplastic epithelial islands."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006179"
    },
    {
      "id": 7902,
      "label": "plexiform ameloblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000487",
          "GARD:0024389",
          "MEDGEN:96838",
          "NCIT:C39753",
          "UMLS:C0457529"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A histologic variant of solid/multicystic ameloblastoma characterized by the presence of basal cells forming anastomosing strands and cords in a delicate stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006381"
    },
    {
      "id": 26172,
      "label": "adenoid ameloblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027425",
          "MEDGEN:1857420",
          "Orphanet:689430",
          "UMLS:C5207962"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975925"
    }
  ],
  "roots": [
    {
      "id": 3040,
      "label": "musculoskeletal system benign neoplasm"
    },
    {
      "id": 20417,
      "label": "odontogenic neoplasm"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm"
    }
  ]
}