{
  "id": 18069,
  "label": "hypersensitivity pneumonitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017853",
  "properties": {
    "xrefs": [
      "DOID:841",
      "GARD:0000012",
      "ICD9:495",
      "ICD9:495.8",
      "ICD9:495.9",
      "MEDGEN:1446",
      "MESH:D000542",
      "MedDRA:10001890",
      "NCIT:C34369",
      "NORD:761",
      "Orphanet:31740",
      "SCTID:37471005",
      "UMLS:C0002390"
    ],
    "synonyms": [
      "HP",
      "allergic form of pneumonitis",
      "allergic pneumonitis",
      "exogen allergic alveolitis",
      "extrinsic allergic alveolitis",
      "hypersensitivity pneumonitis",
      "allergic interstitial pneumonitis",
      "alveolitis, extrinsic allergic",
      "extrinsic allergic pneumonia hypersensitivity pneumonitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Hypersensitivity pneumonitis (HP) is a pulmonary disease with symptoms of dyspnea and cough resulting from the inhalation of an antigen to which the subject has been previously sensitized."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 3133,
      "label": "allergic respiratory disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6815,
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060496",
          "MEDGEN:734246",
          "UMLS:C1504369"
        ],
        "synonyms": [
          "allergic form of respiratory system disease",
          "allergic respiratory system disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A respiratory system disease with a basis in a pathological type I hypersensitivity reaction."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000771"
    },
    {
      "id": 16615,
      "label": "interstitial lung disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3082",
          "EFO:0004244",
          "ICD10CM:J80-J84",
          "MEDGEN:1788738",
          "MESH:D017563",
          "MedDRA:10022611",
          "NCIT:C164315",
          "Orphanet:182095",
          "SCTID:233703007",
          "UMLS:C5441745"
        ],
        "synonyms": [
          "ILD",
          "interstitial lung disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features."
      },
      "child_count": 14,
      "reference_id": "MONDO:0015925"
    },
    {
      "id": 23261,
      "label": "pneumonitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001991",
          "MEDGEN:811420",
          "NCIT:C113159",
          "SCTID:205237003",
          "UMLS:C3714636",
          "icd11.foundation:1324545867"
        ],
        "synonyms": [
          "inflammation of lung parenchyma",
          "lung parenchyma inflammation",
          "pneumonitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia."
      },
      "child_count": 12,
      "reference_id": "MONDO:0043905"
    }
  ],
  "children": [
    {
      "id": 3492,
      "label": "ventilation pneumonitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11289",
          "GARD:0022909",
          "ICD9:495.7",
          "MEDGEN:510127",
          "SCTID:195990006",
          "UMLS:C0155891",
          "icd11.foundation:1414909625"
        ],
        "synonyms": [
          "humidifier lung",
          "humidifiers lung",
          "ventilation systems lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An extrinsic allergic alveolitis caused by inhalation of antigens from thermophilic actinomycetes species growing in air conditioners and humidifiers. Fungi like Aureobasidium sp and Candida albicans that survive in the contaminated water in humidifiers and air conditioners are also known to cause the disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001255"
    },
    {
      "id": 3747,
      "label": "bagassosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12522",
          "GARD:0022962",
          "ICD10CM:J67.1",
          "ICD9:495.1",
          "MEDGEN:2539",
          "NCIT:C34409",
          "SCTID:67242002",
          "UMLS:C0004681",
          "icd11.foundation:1123061945"
        ],
        "synonyms": [
          "bagasse extrinsic allergic alveolitis",
          "bagasse workers lung",
          "extrinsic allergic alveolitis from bagasse"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An occupational lung disorder caused by inhalation of bagasse dust. In the acute phase, it manifests as cough, dyspnea, fever, chills, and weakness. Chronic exposure may lead to interstitial lung fibrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001540"
    },
    {
      "id": 4132,
      "label": "farmer's lung disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14453",
          "GARD:0006427",
          "ICD10CM:J67.0",
          "ICD9:495.0",
          "MEDGEN:8785",
          "MedDRA:10016221",
          "NCIT:C34605",
          "Orphanet:99906",
          "SCTID:18690003",
          "UMLS:C0015634",
          "icd11.foundation:666590509"
        ],
        "synonyms": [
          "farmer lung",
          "farmer's lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A hypersensitivity pneumonitis caused by the repeated exposure and inhalation of biological dust (such as hay dust, mold spores, or other agricultural products). It is considered a type II hypersensitivity inflammatory reaction. In the acute phase, signs and symptoms include fever, chills, cough, dyspnea, headache, and chest tightness. The subacute phase manifests as chronic cough, dyspnea, anorexia, and weight loss. The chronic phase results from the prolonged exposure to the antigen and is characterized by severe dyspnea and irreversible damage to the lungs."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001971"
    },
    {
      "id": 4381,
      "label": "malt worker's lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2808,
        16132,
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2314",
          "GARD:0023103",
          "ICD9:495.4",
          "MEDGEN:510125",
          "SCTID:25897000",
          "UMLS:C0155888"
        ],
        "synonyms": [
          "Aspergillus caused extrinsic allergic alveolitis",
          "Aspergillus extrinsic allergic alveolitis",
          "Malt workers' lung",
          "malt workers lung",
          "alveolitis due to aspergillus clavatus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An extrinsic allergic alveolitis caused by infection with Aspergillus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002266"
    },
    {
      "id": 6348,
      "label": "cork-handlers' disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7386,
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:840",
          "GARD:0024063",
          "ICD10CM:J67.3",
          "ICD9:495.3",
          "MEDGEN:508891",
          "SCTID:13394002",
          "UMLS:C0152108"
        ],
        "synonyms": [
          "Suberosis",
          "cork worker's lung",
          "cork workers lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004549"
    },
    {
      "id": 6380,
      "label": "maple bark strippers' lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420,
        7386,
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8484",
          "GARD:0024073",
          "ICD10CM:J67.6",
          "ICD9:495.6",
          "MEDGEN:510126",
          "SCTID:86638007",
          "UMLS:C0155890"
        ],
        "synonyms": [
          "alveolitis due to cryptostroma corticale",
          "maple bark-strippers' lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A hypersensitivity pneumonitis associated with the inhalation of fungal spores of Cryptostroma corticale in workers stripping the bark from maple and sycamore logs affected by sooty bark disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004584"
    },
    {
      "id": 7302,
      "label": "bird fancier's lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13891",
          "GARD:0016924",
          "ICD10CM:J67.2",
          "ICD9:495.2",
          "MEDGEN:586",
          "MESH:D001716",
          "MedDRA:10004941",
          "NCIT:C34425",
          "Orphanet:99908",
          "SCTID:69339004",
          "UMLS:C0005592",
          "icd11.foundation:912113736"
        ],
        "synonyms": [
          "Avian hypersensitivity pneumonitis",
          "bird fancier lung",
          "bird fancier's lung",
          "bird-fanciers' lung",
          "pigeon-breeder lung disease",
          "pigeon-breeder's lung",
          "bird-breeder's lung",
          "poultry worker's lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Hypersensitivity granulomatous pneumonitis caused by the inhalation of avian antigens that are present in the dust of the droppings and feathers of many species of birds. In the acute phase it manifests as fever, chills, dyspnea, cough, and chest tightness. Chronic exposure may lead to interstitial lung fibrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005668"
    },
    {
      "id": 7473,
      "label": "mushroom workers' lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2708",
          "GARD:0024246",
          "ICD9:495.5",
          "MEDGEN:102344",
          "SCTID:52333004",
          "UMLS:C0155889"
        ],
        "synonyms": [
          "mushroom workers lung",
          "bunashimeji worker's lung",
          "pholiota worker's lung",
          "pleurotus worker's lung",
          "shiitaki worker's lung",
          "shimeji worker's lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005865"
    },
    {
      "id": 7551,
      "label": "sick building syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2710",
          "EFO:0007484",
          "GARD:0024263",
          "MEDGEN:48661",
          "MESH:D018877",
          "SCTID:19076009",
          "UMLS:C0037050"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (alveolitis, extrinsic allergic); allergic rhinitis (rhinitis, allergic, perennial); asthma; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005959"
    },
    {
      "id": 9125,
      "label": "hypersensitivity pneumonitis, familial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069,
        22225
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008240",
          "MEDGEN:326724",
          "MESH:C536846",
          "OMIM:145300",
          "UMLS:C1840386"
        ],
        "synonyms": [
          "hereditary hypersensitivity pneumonitis",
          "hypersensitivity pneumonitis, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An instance of hypersensitivity pneumonitis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007776"
    },
    {
      "id": 17679,
      "label": "idiopathic chronic eosinophilic pneumonia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16617,
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0001130",
          "MEDGEN:443938",
          "MESH:C535590",
          "NORD:967",
          "Orphanet:2902",
          "UMLS:C2930941",
          "icd11.foundation:958353326"
        ],
        "synonyms": [
          "chronic eosinophilic pneumonia",
          "Chronic Eosinophilic Pneumonia",
          "Carrington syndrome",
          "Carrington's disease",
          "Carrington's pulmonary eosinophilia",
          "chronic eosinophilic pneumonia (CEP)",
          "chronic idiopathic eosinophilic pneumonia",
          "eosinophilic idiopathic chronic pneumopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A very rare, severe, interstitial lung disease of insidious onset with subacute or chronic non-specific respiratory manifestations (dyspnea, cough, wheezing) often associated with systemic manifestations (fatigue, malaise, weight loss)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017363"
    },
    {
      "id": 19981,
      "label": "house allergic alveolitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019703",
          "MEDGEN:1387737",
          "Orphanet:99907",
          "SCTID:725415009",
          "UMLS:C4511048",
          "icd11.foundation:1985023223"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A hypersensitivity pneumonitis resulting from the inhalation of an antigen to which an individual has been previously sensitized in his/her domestic environment. House allergic alveolitis encompasses summer hypersensitivity pneumonitis, humidifier-induced lung diseases, hot tub lung and legionellosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020535"
    },
    {
      "id": 26155,
      "label": "non-fibrotic hypersensitivity pneumonitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027410",
          "MEDGEN:1876623",
          "Orphanet:686462",
          "UMLS:C6012350"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975895"
    },
    {
      "id": 26156,
      "label": "fibrotic hypersensitivity pneumonitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18069
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027411",
          "MEDGEN:1808428",
          "Orphanet:686465",
          "UMLS:C5666821"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic, progressive lung disease characterized by inflammation and scarring (fibrosis) of the lung tissue, caused by an immune response to inhaled antigens."
      },
      "child_count": 0,
      "reference_id": "MONDO:0975896"
    }
  ],
  "roots": [
    {
      "id": 3133,
      "label": "allergic respiratory disease"
    },
    {
      "id": 16615,
      "label": "interstitial lung disease"
    },
    {
      "id": 23261,
      "label": "pneumonitis"
    }
  ]
}