{
  "id": 18097,
  "label": "papillary renal cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017884",
  "properties": {
    "xrefs": [
      "DOID:4465",
      "EFO:0000640",
      "GARD:0009572",
      "MEDGEN:266300",
      "NCIT:C6975",
      "ONCOTREE:PRCC",
      "Orphanet:319298",
      "SCTID:733608000",
      "UMLS:C1306837"
    ],
    "synonyms": [
      "HPRCC",
      "chromophil carcinoma of kidney",
      "chromophil carcinoma of the kidney",
      "chromophil renal cell carcinoma",
      "papillary (chromophil) renal cell carcinoma",
      "papillary renal cell adenocarcinoma",
      "papillary renal cell cancer",
      "papillary renal cell carcinoma",
      "renal cell carcinoma, papillary, type 1",
      "RCCP",
      "RCCP1",
      "chromophil RCC",
      "papillary renal carcinoma, malignant - (subtype)",
      "papillary renal cell carcinoma, bilateral - (subtype)",
      "papillary renal cell carcinoma, familial - (subtype)",
      "papillary renal cell carcinoma, multiple - (subtype)",
      "papillary renal cell carcinoma, sporadic - (subtype)",
      "renal adenocarcinoma",
      "renal cell carcinoma, papillary, 1"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4583,
      "label": "papillary adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3112",
          "ICDO:8260/3",
          "MEDGEN:123",
          "MESH:D000231",
          "NCIT:C2853",
          "UMLS:C0001420"
        ],
        "synonyms": [
          "adenocarcinoma, papillary, malignant",
          "papillary adenocarcinoma",
          "papillary adenocarcinoma (morphologic abnormality)",
          "papillary adenocarcinoma NOS (morphologic abnormality)",
          "infiltrating and papillary adenocarcinoma",
          "infiltrating papillary adenocarcinoma"
        ],
        "definition": "A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0002512"
    },
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005708",
          "GARD:0024205",
          "ICDO:8311/1",
          "ICDO:8312/3",
          "NANDO:2200045",
          "NCIT:C9385"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "adenocarcinoma of the kidney",
          "carcinoma, renal cell, malignant",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma",
          "renal cell cancer",
          "renal cell carcinoma, stage unspecified"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005549"
    }
  ],
  "children": [
    {
      "id": 5668,
      "label": "hereditary papillary renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5006,
        18097
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6163",
          "GARD:0013157",
          "MEDGEN:163907",
          "NCIT:C9222",
          "OMIM:605074",
          "Orphanet:47044",
          "SCTID:715561008",
          "UMLS:C0879257"
        ],
        "synonyms": [
          "familial renal papillary carcinoma",
          "hereditary kidney papillary carcinoma",
          "hereditary papillary carcinoma of kidney",
          "hereditary papillary carcinoma of the kidney",
          "hereditary papillary renal carcinoma",
          "hereditary papillary renal cell cancer",
          "hereditary papillary renal cell carcinoma",
          "renal cell carcinoma, papillary",
          "renal cell carcinoma, papillary, 1, familial and somatic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A familial carcinoma inherited in an autosomal dominant trait. It is characterized by the development of multiple, bilateral papillary renal cell carcinomas. The carcinomas range from microscopic lesions to clinically symptomatic tumors. It is associated with activating mutations of the MET oncogene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003789"
    }
  ],
  "roots": [
    {
      "id": 4583,
      "label": "papillary adenocarcinoma"
    },
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma"
    }
  ]
}