{
  "id": 18098,
  "label": "chromophobe renal cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017885",
  "properties": {
    "xrefs": [
      "DOID:4471",
      "EFO:0000335",
      "GARD:0006064",
      "ICDO:8270/3",
      "ICDO:8317/3",
      "MEDGEN:266091",
      "NCIT:C4146",
      "ONCOTREE:CHRCC",
      "Orphanet:319303",
      "SCTID:733471003",
      "UMLS:C1266042"
    ],
    "synonyms": [
      "chromophobe adenocarcinoma",
      "chromophobe carcinoma",
      "chromophobe carcinoma of kidney",
      "chromophobe carcinoma of the kidney",
      "chromophobe cell carcinoma of kidney",
      "chromophobe cell carcinoma of the kidney",
      "chromophobe renal cell adenocarcinoma",
      "chromophobe renal cell cancer",
      "chromophobe renal cell carcinoma",
      "renal cell carcinoma, chromophobe type",
      "CHRCC",
      "CRCC",
      "ChRCC"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Chromophobe renal cell carcinoma is a rare subtype of renal cell carcinoma, originating from the intercalating cells of the collecting ducts and macroscopically manifesting as a well-circumscribed, highly lobulated, solid tumor that is usually diagnosed at an early stage. It is frequently asymptomatic, or may present with nonspecific symptoms, such as weight loss, fever or fatigue. The classic presentation observed in renal tumors (hematuria, flank pain and palpable mass) is occasionally observed and usually indicates an advanced stage of the disease. It is most frequently sporadic however, several familial cases, associated with Birt-Hogg DubC) syndrome, have been described."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005708",
          "GARD:0024205",
          "ICDO:8311/1",
          "ICDO:8312/3",
          "NANDO:2200045",
          "NCIT:C9385"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "adenocarcinoma of the kidney",
          "carcinoma, renal cell, malignant",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma",
          "renal cell cancer",
          "renal cell carcinoma, stage unspecified"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005549"
    }
  ],
  "children": [
    {
      "id": 5800,
      "label": "classic variant of chromophobe renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18098
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6605",
          "GARD:0023746",
          "MEDGEN:232080",
          "NCIT:C27888",
          "UMLS:C1333062"
        ],
        "synonyms": [
          "classic variant of chromophobe renal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0003941"
    },
    {
      "id": 5801,
      "label": "eosinophilic variant of chromophobe renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18098
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6606",
          "GARD:0023747",
          "MEDGEN:232458",
          "NCIT:C27889",
          "UMLS:C1333405"
        ],
        "synonyms": [
          "eosinophilic variant of chromophobe renal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0003942"
    }
  ],
  "roots": [
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma"
    }
  ]
}