{
  "id": 18103,
  "label": "inherited acute myeloid leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017893",
  "properties": {
    "xrefs": [
      "GARD:0017450",
      "MEDGEN:1634915",
      "NCIT:C7175",
      "Orphanet:319465",
      "SCTID:764940002",
      "UMLS:C4707228"
    ],
    "synonyms": [
      "Pure familial AML",
      "Pure familial acute myeloid leukaemia",
      "Pure familial acute myeloid leukemia",
      "familial AML",
      "hereditary acute myeloid leukaemia",
      "hereditary acute myeloid leukemia",
      "inherited AML"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An instance of acute myeloid leukemia that is caused by an inherited modification of the individual's genome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18806,
      "label": "acute myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9119",
          "EFO:0000222",
          "GARD:0012757",
          "ICD10CM:C92.0",
          "ICD9:205.0",
          "ICD9:205.00",
          "ICDO:9861/3",
          "MEDGEN:9730",
          "MESH:D015470",
          "MedDRA:10000880",
          "NCIT:C3171",
          "NORD:1905",
          "OMIM:601626",
          "ONCOTREE:AML",
          "Orphanet:519",
          "SCTID:91861009",
          "UMLS:C0023467"
        ],
        "synonyms": [
          "AML",
          "AML - acute myeloid leukaemia",
          "AML - acute myeloid leukemia",
          "ANLL",
          "acute Nonlymphocytic leukaemia",
          "acute Nonlymphocytic leukemia",
          "acute granulocytic leukaemia",
          "acute granulocytic leukemia",
          "acute myeloblastic leukemia",
          "acute myelocytic leukaemia",
          "acute myelocytic leukemia",
          "acute myelogenous leukemia",
          "acute myelogenous leukemias",
          "acute myeloid leukaemia (AML)",
          "acute myeloid leukemia",
          "acute myeloid leukemia (AML)",
          "acute myeloid leukemia, somatic",
          "acute nonlymphocytic leukaemia",
          "acute nonlymphocytic leukemia",
          "hematopoeitic - acute Myleogenous leukaemia (AML)",
          "hematopoeitic - acute Myleogenous leukemia (AML)",
          "leukemia, acute myeloid, autosomal dominant, somatic mutation",
          "leukemia, acute myeloid, reduced survival in, somatic",
          "leukemia, acute myeloid, somatic",
          "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation",
          "leukemia, myelocytic, acute",
          "myeloid leukemia, acute",
          "myeloid leukemia, acute, M4/M4Eo subtype, somatic",
          "acute non lymphoblastic leukaemia",
          "acute non lymphoblastic leukemia",
          "leukemia, acute myelogenous",
          "leukemia, acute myeloid",
          "leukemia, acute myeloid, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections."
      },
      "child_count": 156,
      "reference_id": "MONDO:0018874"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:473110",
          "NCIT:C97075",
          "SCTID:363045008",
          "UMLS:C0410787"
        ],
        "synonyms": [
          "Mendelian connective tissue disorder",
          "connective tissue hereditary disorder",
          "hereditary connective tissue disorder",
          "Hereditary Connective Tissue Disorder",
          "Inherited disorder of connective tissue",
          "inherited disorder of connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An inherited genetic disorder that affects the connective tissues. Representative examples include Ehlers-Danlos syndrome and Marfan syndrome."
      },
      "child_count": 176,
      "reference_id": "MONDO:0023603"
    }
  ],
  "children": [
    {
      "id": 13923,
      "label": "acute promyelocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18103
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060318",
          "DOID:0081081",
          "EFO:0000224",
          "GARD:0000538",
          "ICD10CM:C92.4",
          "ICDO:9866/3",
          "MEDGEN:44127",
          "MESH:D015473",
          "MedDRA:10001019",
          "NANDO:2200007",
          "NCIT:C3182",
          "NORD:2003",
          "OMIM:612376",
          "Orphanet:520",
          "SCTID:110004001",
          "UMLS:C0023487"
        ],
        "synonyms": [
          "AML M3",
          "AML with t(15;17)(q22;q12)",
          "AML with t(15;17)(q22;q12);(PML/RARalpha) and variants",
          "APL",
          "APML",
          "APML - acute promyelocytic leukaemia",
          "APML - acute promyelocytic leukemia",
          "FAB M3",
          "acute myeloblastic leukaemia 3",
          "acute myeloblastic leukemia 3",
          "acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variants",
          "acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants",
          "acute promyelocytic leukaemia with PML-rara",
          "acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-rara",
          "acute promyelocytic leukaemia with t(15;17)(q22;q12); PML/rara",
          "acute promyelocytic leukemia",
          "acute promyelocytic leukemia with PML-rara",
          "acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara",
          "acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara",
          "leukemia, acute promyelocytic, somatic",
          "promyelocytic leukaemia",
          "promyelocytic leukemia",
          "leukemia, acute promyelocytic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012883"
    },
    {
      "id": 22874,
      "label": "mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18103,
        20146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022354",
          "ICD10CM:C92.7",
          "MEDGEN:414807",
          "Orphanet:589534",
          "UMLS:C2826037"
        ],
        "synonyms": [
          "MPAL with t(9;22)(q34.1;q11.2); BCR-ABL1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035639"
    },
    {
      "id": 22875,
      "label": "mixed phenotype acute leukemia with t(v;11q23.3)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18103,
        20146
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022357",
          "ICD10CM:C92.6",
          "MEDGEN:443130",
          "NCIT:C82203",
          "Orphanet:589595",
          "UMLS:C2826048"
        ],
        "synonyms": [
          "MPAL with t(v;11q23.3); KMT2A rearranged",
          "MPAL with t(v;11q23.3); MLL rearranged"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035642"
    }
  ],
  "roots": [
    {
      "id": 18806,
      "label": "acute myeloid leukemia"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue"
    }
  ]
}