{
  "id": 18113,
  "label": "amyloidosis cutis dyschromia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017906",
  "properties": {
    "xrefs": [
      "DOID:0080932",
      "GARD:0017466",
      "MEDGEN:1641859",
      "Orphanet:319635",
      "UMLS:C4554601"
    ],
    "synonyms": [
      "amyloidosis cutis dyschromica"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Amyloidosis cutis dyschromia is a rare primary cutaneous amyloidosis characterized by macular or reticulate hyperpigmentation with symmetrically distributed guttate hypo- and hyperpigmented lesions which progress gradually over the years to involve almost the entire body (with relative sparing of the face, hands, feet and neck). Patients are usually asymptomatic, however mild pruritus may be associated. Amyloid deposition in the papillary dermis is observed on skin biopsy. Systemic amyloidosis is not present and association with generalized morphea, atypical Parkinsonism, spasticity, motor weakness or colon carcinoma is rare."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16181,
      "label": "primary cutaneous amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18960,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050639",
          "GARD:0000132",
          "MEDGEN:120635",
          "MESH:C562642",
          "MedDRA:10011659",
          "NCIT:C199391",
          "Orphanet:137807",
          "SCTID:282834007",
          "UMLS:C0268397"
        ],
        "synonyms": [
          "primary localised cutaneous amyloidosis",
          "primary localized cutaneous amyloidosis",
          "PLCA",
          "familial primary localised cutaneous amyloidosis",
          "familial primary localized cutaneous amyloidosis",
          "amyloidosis IX",
          "amyloidosis familial cutaneous lichen",
          "amyloidosis, primary localised cutaneous",
          "amyloidosis, primary localized cutaneous",
          "lichen amyloidosis familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Cutaneous amyloidosis refers to a variety of skin diseases characterized histologically by the extracellular accumulation of amyloid deposits in the dermis. Rare forms include lichen amyloidosus, X-linked reticulate pigmentary disorder, primary localized cutaneous nodular amyloidosis, and macular amyloidosis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015301"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16181,
      "label": "primary cutaneous amyloidosis"
    }
  ]
}