{
  "id": 18191,
  "label": "goblet cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018017",
  "properties": {
    "xrefs": [
      "GARD:0010414",
      "ICDO:8243/3",
      "MEDGEN:60007",
      "NCIT:C3689",
      "NORD:1931",
      "ONCOTREE:GCCAP",
      "Orphanet:329984",
      "UMLS:C0205695"
    ],
    "synonyms": [
      "GCC",
      "Goblet Cell Adenocarcinoma",
      "appendix adenocarcinoid tumor",
      "appendix adenocarcinoid tumour",
      "appendix goblet cell carcinoid",
      "appendix goblet cell carcinoid tumor",
      "appendix goblet cell carcinoid tumour",
      "appendix mixed carcinoid-adenocarcinoma",
      "carcinoma of goblet cell",
      "goblet cell adenocarcinoid",
      "goblet cell carcinoid",
      "goblet cell carcinoid of appendix",
      "goblet cell carcinoid of the appendix",
      "goblet cell carcinoid tumor",
      "goblet cell carcinoid tumour",
      "goblet cell carcinoma",
      "goblet cell tumor",
      "goblet cell tumour",
      "mucinous carcinoid tumor",
      "mucinous carcinoid tumour",
      "mucinous carcinoid"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive type of endocrine tumor of the appendix presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 5155,
      "label": "appendix carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3475,
        7615,
        18543
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4902",
          "GARD:0023407",
          "MEDGEN:196398",
          "NCIT:C9330",
          "SCTID:448992002",
          "UMLS:C0728951"
        ],
        "synonyms": [
          "appendix cancer",
          "appendix carcinoma",
          "carcinoma of appendix",
          "carcinoma of the appendix",
          "carcinoma of vermiform appendix",
          "vermiform appendix carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the vermiform appendix"
      },
      "child_count": 9,
      "reference_id": "MONDO:0003196"
    },
    {
      "id": 16040,
      "label": "neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16041,
        18543,
        21454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019754",
          "MEDGEN:474400",
          "NCIT:C96422",
          "ONCOTREE:AWDNET",
          "Orphanet:100079",
          "SCTID:725167001",
          "UMLS:C3272767",
          "icd11.foundation:1590340268"
        ],
        "synonyms": [
          "NEN of appendix",
          "appendiceal NEN",
          "appendiceal neuroendocrine neoplasm",
          "appendiceal neuroendocrine tumor",
          "appendiceal neuroendocrine tumour",
          "appendix NET",
          "appendix neuroendocrine tumor",
          "appendix neuroendocrine tumour",
          "appendix well differentiated endocrine tumor",
          "appendix well differentiated endocrine tumor/carcinoma",
          "appendix well differentiated endocrine tumour",
          "neuroendocrine neoplasm of appendix",
          "well-differentiated neuroendocrine tumor of the appendix",
          "well-differentiated neuroendocrine tumour of the appendix"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the appendix."
      },
      "child_count": 12,
      "reference_id": "MONDO:0015066"
    },
    {
      "id": 20711,
      "label": "combined carcinoid and adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005741",
          "ICDO:8244/3",
          "ICDO:8245/3",
          "MEDGEN:83124",
          "MESH:C538230",
          "NCIT:C4139",
          "UMLS:C0334302"
        ],
        "synonyms": [
          "adenocarcinoid neoplasm",
          "adenocarcinoid tumor",
          "adenocarcinoid tumour",
          "combined carcinoid and adenocarcinoma",
          "combined carcinoid neoplasm and adenocarcinoma",
          "combined carcinoid tumor and adenocarcinoma",
          "combined carcinoid tumour and adenocarcinoma",
          "composite carcinoid",
          "composite carcinoid neoplasm",
          "composite carcinoid tumor",
          "composite carcinoid tumour",
          "mixed carcinoid neoplasm",
          "mixed carcinoid tumor",
          "mixed carcinoid tumour"
        ],
        "definition": "A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells."
      },
      "child_count": 1,
      "reference_id": "MONDO:0021659"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 5155,
      "label": "appendix carcinoma"
    },
    {
      "id": 16040,
      "label": "neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade"
    },
    {
      "id": 20711,
      "label": "combined carcinoid and adenocarcinoma"
    }
  ]
}