{
  "id": 18235,
  "label": "persistent truncus arteriosus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018072",
  "properties": {
    "xrefs": [
      "GARD:0016627",
      "ICD10CM:Q20.0",
      "MEDGEN:52867",
      "MESH:D014339",
      "NANDO:1200693",
      "NANDO:2200261",
      "NCIT:C98880",
      "NORD:1800",
      "Orphanet:3384",
      "UMLS:C0041207",
      "icd11.foundation:1832500366"
    ],
    "synonyms": [
      "TAC",
      "Truncus Arteriosus",
      "common aorticopulmonary trunk",
      "common arterial trunk",
      "common truncus arteriosus",
      "persistent truncus arteriosus",
      "persistent truncus arteriosus (disease)",
      "truncus arteriosus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A rare congenital cardiovascular disorder characterized by the failure of the embryologic structure truncus arteriosus to divide into the aorta and pulmonary trunk. It results in the presence of a single vessel instead of two vessels leading out of the heart. Clinical signs and symptoms include cyanosis that is present at birth, poor growth, dyspnea, tachypnea, arrhythmia, cardiomegaly, and heart failure. If it is not surgically repaired, it leads to death."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7116,
      "label": "congenital heart disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6967,
        21294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1682",
          "EFO:0005207",
          "ICD9:746.84",
          "ICD9:746.89",
          "ICD9:746.9",
          "MEDGEN:57501",
          "MESH:D006330",
          "NCIT:C95834",
          "SCTID:13213009",
          "UMLS:C0152021",
          "icd11.foundation:2004408087"
        ],
        "synonyms": [
          "heart malformation",
          "congenital anomaly of heart",
          "congenital heart defect",
          "congenital heart defects",
          "Abnormality, heart",
          "abnormalities, heart",
          "defect, congenital heart",
          "defects, congenital heart",
          "heart abnormalities",
          "heart abnormality",
          "heart defect, congenital",
          "heart, malformation Of"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale."
      },
      "child_count": 46,
      "reference_id": "MONDO:0005453"
    },
    {
      "id": 17072,
      "label": "conotruncal heart malformations",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19327
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008189",
          "ICD9:747.11",
          "MEDGEN:341803",
          "NANDO:2200275",
          "OMIM:217095",
          "Orphanet:2445",
          "SCTID:218728005",
          "UMLS:C1857586"
        ],
        "synonyms": [
          "Taussig-Bing syndrome or defect",
          "conotruncal heart malformations",
          "conotruncal heart malformations, variable",
          "CTHM",
          "Double-outlet right ventricle",
          "conotruncal anomaly face syndrome",
          "conotruncal cardiac defects",
          "interrupted aortic Arch",
          "persistent truncus arteriosus",
          "truncus arteriosus communis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Conotruncal heart malformations are a group of congenital cardiac outflow tract anomalies that include such defects as tetralogy of Fallot, pulmonary atresia with ventricular septal defect, double-outlet right ventricle (DORV), double-outlet left ventricle, truncus arteriosus and transposition of the great arteries (TGA), among others. This group of defects is frequently found in patients with 22q11.2 deletion syndrome. A deletion of chromosome 22q11.2 has equally been associated in a subset of patients with various types of isolated non-syndromic conotruncal heart malformations (with the exception of DORV and TGA where this is very uncommon)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016581"
    }
  ],
  "children": [
    {
      "id": 26047,
      "label": "common arterial trunk with aortic dominance",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027179",
          "MEDGEN:1622872",
          "Orphanet:665044",
          "UMLS:C4546067",
          "icd11.foundation:551770382"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971107"
    },
    {
      "id": 26048,
      "label": "common arterial trunk with pulmonary dominance and interrupted aortic arch",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027180",
          "MEDGEN:1612764",
          "Orphanet:665058",
          "UMLS:C4546068",
          "icd11.foundation:97579611"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971108"
    }
  ],
  "roots": [
    {
      "id": 7116,
      "label": "congenital heart disease"
    },
    {
      "id": 17072,
      "label": "conotruncal heart malformations"
    }
  ]
}