{
  "id": 18237,
  "label": "tuberculosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018076",
  "properties": {
    "xrefs": [
      "DOID:399",
      "GARD:0007827",
      "ICD10CM:A15-A19",
      "ICD10WHO:A15-A19",
      "ICD9:017.90",
      "ICD9:017.92",
      "ICD9:017.94",
      "ICD9:017.96",
      "MEDGEN:22513",
      "MESH:D014376",
      "MedDRA:10044755",
      "NCIT:C3423",
      "NORD:1801",
      "Orphanet:3389",
      "SCTID:56717001",
      "UMLS:C0041296",
      "icd11.foundation:2072728114"
    ],
    "synonyms": [
      "tuberculosis disease",
      "active tuberculosis",
      "Kochs disease",
      "TB"
    ],
    "definition": "A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 2837,
      "label": "primary bacterial infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050338"
        ]
      },
      "child_count": 37,
      "reference_id": "MONDO:0000314"
    },
    {
      "id": 20027,
      "label": "mycobacterial infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:6479",
          "MESH:D009164",
          "NCIT:C26831",
          "SCTID:88415009",
          "UMLS:C0026918"
        ],
        "synonyms": [
          "mycobacterial infection",
          "mycobacteriosis",
          "mycobacterium infection"
        ],
        "definition": "Infection due to organisms from the genus Mycobacteria."
      },
      "child_count": 7,
      "reference_id": "MONDO:0020590"
    }
  ],
  "children": [
    {
      "id": 2868,
      "label": "extrapulmonary tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050598",
          "GARD:0022756",
          "MEDGEN:671310",
          "SCTID:423997002",
          "UMLS:C0679362"
        ],
        "definition": "A tuberculosis that occurs at body sites other than the lung."
      },
      "child_count": 13,
      "reference_id": "MONDO:0000368"
    },
    {
      "id": 7636,
      "label": "pulmonary tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6815,
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2957",
          "EFO:1000049",
          "GARD:0024276",
          "ICD9:011",
          "ICD9:011.16",
          "ICD9:011.80",
          "ICD9:011.81",
          "ICD9:011.84",
          "ICD9:011.85",
          "ICD9:011.86",
          "ICD9:011.9",
          "ICD9:011.90",
          "ICD9:011.92",
          "ICD9:011.96",
          "MEDGEN:11947",
          "MESH:D014397",
          "NCIT:C26899",
          "SCTID:154283005",
          "UMLS:C0041327"
        ],
        "synonyms": [
          "lung TB",
          "lung tuberculosis",
          "pulmonary TB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A bacterial infection that affects the lungs and is caused by Mycobacterium tuberculosis. Most patients with tuberculosis do not have symptoms (latent tuberculosis) and are not contagious. When signs and symptoms occur (active tuberculosis), patients become contagious. The signs and symptoms include chronic cough with blood-tinged sputum, night sweats, fever, fatigue, and weight loss."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006052"
    },
    {
      "id": 8200,
      "label": "endocrine tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024464",
          "MEDGEN:52884",
          "MESH:D014383",
          "UMLS:C0041310"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Infection of the endocrine glands with species of mycobacterium, most often mycobacterium tuberculosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006743"
    },
    {
      "id": 20786,
      "label": "tuberculoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025356",
          "MEDGEN:52881",
          "MESH:D014375",
          "SCTID:15202009",
          "UMLS:C0041295"
        ],
        "synonyms": [
          "Tuberculoma",
          "Tuberculomas"
        ],
        "definition": "A tumor-like mass resulting from the enlargement of a tuberculous lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021943"
    },
    {
      "id": 23012,
      "label": "latent tuberculosis infection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025831",
          "MEDGEN:294255",
          "MESH:D055985",
          "SCTID:11999007",
          "UMLS:C1609538"
        ],
        "synonyms": [
          "LTBI",
          "inactive TB",
          "inactive tuberculosis",
          "tuberculosis infection latent"
        ],
        "definition": "Mycobacterium tuberculosis infection that does not induce infectious expression of the disease in the affected person, although it can cause continuous immune response generated towards TB antigens; person having LTBI are asymptomatic and acting as a reservoir of active tuberculosis tuberculosis cases and Mycobacterium tuberculosis and run a 5-10% risk of reactivating tuberculosis throughout their lives."
      },
      "child_count": 0,
      "reference_id": "MONDO:0040753"
    },
    {
      "id": 23045,
      "label": "drug-resistant tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025841",
          "MEDGEN:61616",
          "SCTID:423709000",
          "UMLS:C0206525"
        ],
        "synonyms": [
          "drug resistant tuberculosis"
        ],
        "definition": "Tuberculosis disease caused by Mycobacterium tuberculosis isolate that is resistant to one or more of the antitubercular medications."
      },
      "child_count": 4,
      "reference_id": "MONDO:0041806"
    },
    {
      "id": 24207,
      "label": "active tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026239",
          "MEDGEN:508753",
          "UMLS:C0151332"
        ],
        "synonyms": [
          "active TB"
        ],
        "definition": "Tuberculosis caused by primary infection of or reactivation of latent Mycobacterium tuberculosis. Active tuberculosis characterized by clinical manifestation and active symptoms compatible with tuberculosis, and is distinct from latent tuberculosis infection that occurs without signs or symptoms of active disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100481"
    },
    {
      "id": 25218,
      "label": "tuberculous encephalopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080995",
          "GARD:0026613"
        ],
        "definition": "A tuberculosis that is characterized by cerebral edema sometimes with features similar to acute disseminated encephalomyelitis (ADEM) and may manifest with a variety of symptoms ranging from focal neurological deficits to convulsions and decreased conscious state."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850417"
    },
    {
      "id": 25685,
      "label": "primary tuberculous lymphadenitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026840",
          "MEDGEN:1843412",
          "Orphanet:645807",
          "UMLS:C5816704",
          "icd11.foundation:870345553"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957461"
    },
    {
      "id": 25687,
      "label": "primary bone and joint tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026842",
          "MEDGEN:1843400",
          "Orphanet:645822",
          "UMLS:C5816705"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957463"
    },
    {
      "id": 25689,
      "label": "multifocal tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026844",
          "MEDGEN:1843417",
          "Orphanet:645854",
          "UMLS:C5816701"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957465"
    },
    {
      "id": 25690,
      "label": "primary tuberculosis of the digestive system",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18237
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026845",
          "MEDGEN:1843420",
          "Orphanet:645859",
          "UMLS:C5816702",
          "icd11.foundation:1873777499"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957466"
    }
  ],
  "roots": [
    {
      "id": 2837,
      "label": "primary bacterial infectious disease"
    },
    {
      "id": 20027,
      "label": "mycobacterial infectious disease"
    }
  ]
}