{
  "id": 18300,
  "label": "lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018155",
  "properties": {
    "xrefs": [
      "DOID:230",
      "GARD:0010684",
      "ICD10CM:G12.23",
      "ICD9:335.24",
      "MEDGEN:57591",
      "MedDRA:10036704",
      "NANDO:1200008",
      "NCIT:C129933",
      "Orphanet:35689",
      "SCTID:81211007",
      "UMLS:C0154682",
      "icd11.foundation:1686688462"
    ],
    "synonyms": [
      "PLS",
      "adult-onset PLS",
      "adult-onset primary lateral sclerosis",
      "primary lateral sclerosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 21302,
      "label": "hereditary motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19749,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019478",
          "MEDGEN:78728",
          "Orphanet:98505",
          "SCTID:49793008",
          "UMLS:C0270763"
        ],
        "synonyms": [
          "genetic anterior horn cell disease",
          "genetic motor neuron disease",
          "hereditary motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of motor neuron disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 27,
      "reference_id": "MONDO:0024257"
    }
  ],
  "children": [
    {
      "id": 12755,
      "label": "juvenile primary lateral sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18300,
        23968
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004485",
          "MEDGEN:342870",
          "MESH:C536416",
          "OMIM:606353",
          "Orphanet:247604",
          "SCTID:717964007",
          "UMLS:C1853396"
        ],
        "synonyms": [
          "JPLS",
          "juvenile PLS",
          "PLS juvenile",
          "PLSJ",
          "Pls, juvenile",
          "primary lateral sclerosis, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Juvenile primary lateral sclerosis (JPLS) is a very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011663"
    },
    {
      "id": 13748,
      "label": "primary lateral sclerosis, adult, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18300
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024885",
          "MEDGEN:369357",
          "MESH:C566900",
          "OMIM:611637",
          "UMLS:C1968845"
        ],
        "synonyms": [
          "PLSA1",
          "Pls, adult",
          "primary lateral sclerosis, ADULT, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012708"
    }
  ],
  "roots": [
    {
      "id": 21302,
      "label": "hereditary motor neuron disease"
    }
  ]
}