{
  "id": 18310,
  "label": "oral submucous fibrosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018166",
  "properties": {
    "xrefs": [
      "DOID:5773",
      "EFO:1001818",
      "GARD:0007264",
      "ICD10CM:K13.5",
      "ICD9:528.8",
      "MEDGEN:45213",
      "MESH:D009914",
      "NCIT:C34866",
      "Orphanet:357154",
      "SCTID:32883009",
      "UMLS:C0029172",
      "icd11.foundation:1798376929"
    ],
    "synonyms": [
      "OSMF",
      "oral cavity submucous fibrosis",
      "oral submucosal fibrosis, including of tongue"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 8301,
      "label": "mouth disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:403",
          "EFO:1001047",
          "ICD9:528.9",
          "MEDGEN:6448",
          "MESH:D009059",
          "NCIT:C3240",
          "SCTID:118938008",
          "UMLS:C0026636"
        ],
        "synonyms": [
          "disease of mouth",
          "disease or disorder of mouth",
          "disorder of mouth",
          "mouth disease",
          "mouth disease or disorder",
          "oral disease",
          "oral disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A disease involving the mouth."
      },
      "child_count": 27,
      "reference_id": "MONDO:0006858"
    },
    {
      "id": 21213,
      "label": "disorder of facial skeleton",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:712533",
          "UMLS:C1290148"
        ],
        "synonyms": [
          "disease of facial skeleton",
          "disease or disorder of facial skeleton",
          "disorder of facial skeleton",
          "facial skeleton disease",
          "facial skeleton disease or disorder",
          "maxillo-facial disease",
          "maxillofacial anomaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disease that involves the facial skeleton."
      },
      "child_count": 20,
      "reference_id": "MONDO:0023369"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 8301,
      "label": "mouth disorder"
    },
    {
      "id": 21213,
      "label": "disorder of facial skeleton"
    }
  ]
}