{
  "id": 18315,
  "label": "malignant germ cell tumor of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018171",
  "properties": {
    "xrefs": [
      "DOID:2155",
      "GARD:0009330",
      "MEDGEN:87544",
      "NCIT:C4514",
      "Orphanet:35807",
      "SCTID:254869000",
      "UMLS:C0346180"
    ],
    "synonyms": [
      "MOGCT",
      "malignant germ cell neoplasm of ovary",
      "malignant germ cell neoplasm of the ovary",
      "malignant germ cell tumor of ovary",
      "malignant germ cell tumor of the ovary",
      "malignant germ cell tumour of the ovary",
      "malignant ovarian germ cell neoplasm",
      "malignant ovarian germ cell tumor",
      "malignant ovarian germ cell tumour",
      "ovarian germ cell cancer",
      "ovary malignant germ cell tumor",
      "ovary malignant germ cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7832,
      "label": "malignant germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000352",
          "GARD:0003360",
          "MEDGEN:890580",
          "NCIT:C4925",
          "SCTID:145831000119103",
          "UMLS:C4048549"
        ],
        "synonyms": [
          "cancer of germ cell",
          "germ cell cancer",
          "germ cell tumor, malignant",
          "malignant germ cell neoplasm",
          "malignant germ cell tumor",
          "malignant neoplasm of germ cell",
          "malignant neoplasm of the germ cell",
          "malignant tumor of germ cell",
          "malignant tumor of the germ cell",
          "malignant tumour of germ cell",
          "malignant tumour of the germ cell"
        ],
        "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0006290"
    },
    {
      "id": 12476,
      "label": "ovarian germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2156",
          "EFO:1000419",
          "GARD:0024792",
          "ICD9:239.5",
          "MEDGEN:65958",
          "NCIT:C3873",
          "OMIM:603737",
          "ONCOTREE:OGCT",
          "SCTID:237059008",
          "UMLS:C0238324"
        ],
        "synonyms": [
          "germ cell neoplasm of ovary",
          "germ cell neoplasm of the ovary",
          "germ cell tumor of ovary",
          "germ cell tumor of the ovary",
          "germ cell tumour of ovary",
          "germ cell tumour of the ovary",
          "ovarian germ cell neoplasm",
          "ovarian germ cell tumor",
          "ovary germ cell tumor",
          "ovary germ cell tumour",
          "ovarian germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0011366"
    },
    {
      "id": 18335,
      "label": "gonadal germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021554",
          "Orphanet:363582"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0018202"
    },
    {
      "id": 18448,
      "label": "malignant non-epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021650",
          "MEDGEN:1843209",
          "Orphanet:398940",
          "UMLS:C5680039"
        ],
        "synonyms": [
          "non-epithelial cancer of ovary",
          "ovarian malignant non-epithelial tumor",
          "ovarian malignant non-epithelial tumour",
          "ovarian non-epithelial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018365"
    }
  ],
  "children": [
    {
      "id": 5339,
      "label": "ovarian primitive germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5351",
          "GARD:0023506",
          "MEDGEN:275291",
          "NCIT:C39986",
          "UMLS:C1518727"
        ],
        "synonyms": [
          "ovarian primitive germ cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003408"
    },
    {
      "id": 5421,
      "label": "choriocarcinoma of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6924,
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5550",
          "EFO:1000413",
          "GARD:0023536",
          "MEDGEN:91089",
          "NCIT:C4515",
          "SCTID:254870004",
          "UMLS:C0346181"
        ],
        "synonyms": [
          "choriocarcinoma of ovary",
          "choriocarcinoma of the ovary",
          "germ cell choriocarcinoma of ovary",
          "germ cell choriocarcinoma of the ovary",
          "ovarian choriocarcinoma",
          "ovarian germ cell choriocarcinoma",
          "ovary choriocarcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A choriocarcinoma arising from the ovary. When it appears before puberty is of germ cell origin. In children and young adults signs and symptoms include precocious pseudopuberty and vaginal bleeding. Serum human chorionic gonadotropin is elevated. Germ cell derived ovarian choriocarcinoma should be differentiated from primary or metastatic gestational choriocarcinoma affecting the ovary. The prognosis of germ cell derived choriocarcinoma is less favorable and requires more aggressive chemotherapy treatment regimens compared to gestational choriocarcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003507"
    },
    {
      "id": 17646,
      "label": "primary non-gestational choriocarcinoma of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021136",
          "MEDGEN:906353",
          "Orphanet:289356",
          "SCTID:716588005",
          "UMLS:C4274424"
        ],
        "synonyms": [
          "NGCO",
          "primary non-gestational ovarian choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Primary non-gestational choriocarcinoma of ovary is a rare ovarian germ cell malignant tumor, arising from primordial germ cells, usually presenting with nausea, vomiting, abdominal pain, menstrual irregularities, and characterized by fast growth pattern, metastasis to lung, liver and brain and production of human chorionic gonadotrophin (hCG). It is apparently chemoresistant and has a worse prognosis than gestational choriocarcinoma and hence should be distinguished from the latter by DNA polymorphism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017327"
    },
    {
      "id": 19982,
      "label": "malignant dysgerminomatous germ cell tumor of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019705",
          "Orphanet:99912"
        ],
        "synonyms": [
          "dysgerminomatous germ cell cancer of ovary",
          "dysgerminomatous germ cell cancer of the ovary",
          "malignant ovarian dysgerminoma",
          "malignant dysgerminomatous germ cell tumor of the ovary",
          "malignant dysgerminomatous germ cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant dysgerminomatous germ cell tumor of ovary is the most common form of malignant germ cell tumor of ovary, arising from germ cells in the ovary, usually presenting during adolescence with pelvic mass, fever, vaginal bleeding, and acute abdomen and is characterized by bilaterality (around 10% of cases), association with dysgenetic gonads (5 to 10% of cases), elevated serum lactate dehydrogenase (LDH) and human chorionic gonadotrophin (hCG) (in the presence of syncitiotrophoblasts). Malignant dysgerminomatous germ cell tumor of ovary responds well to chemotherapy, potentially sparing patients from infertility and early mortality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020538"
    }
  ],
  "roots": [
    {
      "id": 7832,
      "label": "malignant germ cell tumor"
    },
    {
      "id": 12476,
      "label": "ovarian germ cell tumor"
    },
    {
      "id": 18335,
      "label": "gonadal germ cell tumor"
    },
    {
      "id": 18448,
      "label": "malignant non-epithelial tumor of ovary"
    }
  ]
}