{
  "id": 18316,
  "label": "malignant sex cord stromal tumor of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018172",
  "properties": {
    "xrefs": [
      "GARD:0018816",
      "MEDGEN:233667",
      "NCIT:C8053",
      "Orphanet:35808",
      "UMLS:C1334609"
    ],
    "synonyms": [
      "malignant Sex cord-stromal tumor of ovary",
      "malignant Sex cord-stromal tumor of the ovary",
      "malignant Sex cord-stromal tumour of ovary",
      "malignant Sex cord-stromal tumour of the ovary",
      "malignant ovarian SCST",
      "malignant ovarian Sex cord-stromal neoplasm",
      "malignant ovarian Sex cord-stromal tumor",
      "malignant ovarian Sex cord-stromal tumour",
      "malignant ovarian sex cord-stromal tumor",
      "malignant ovarian sex cord-stromal tumour",
      "ovarian sex cord-stromal tumor, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 18448,
      "label": "malignant non-epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021650",
          "MEDGEN:1843209",
          "Orphanet:398940",
          "UMLS:C5680039"
        ],
        "synonyms": [
          "non-epithelial cancer of ovary",
          "ovarian malignant non-epithelial tumor",
          "ovarian malignant non-epithelial tumour",
          "ovarian non-epithelial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018365"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080369",
          "GARD:0012285",
          "MEDGEN:154644",
          "NCIT:C4862",
          "ONCOTREE:SCST",
          "UMLS:C0600113"
        ],
        "synonyms": [
          "Sex cord-stromal neoplasm of ovary",
          "Sex cord-stromal neoplasm of the ovary",
          "Sex cord-stromal tumor of ovary",
          "Sex cord-stromal tumor of the ovary",
          "Sex cord-stromal tumour of ovary",
          "Sex cord-stromal tumour of the ovary",
          "ovarian Sex cord-stromal neoplasm",
          "ovarian Sex cord-stromal tumor",
          "ovarian Sex cord-stromal tumour",
          "ovary sex cord-stromal tumor",
          "ovary sex cord-stromal tumour",
          "sex cord-stromal tumor of ovary",
          "sex cord-stromal tumour of ovary",
          "ovarian sex cord tumor with annular tubules",
          "ovarian sex cord tumour with annular tubules",
          "sex cord stromal tumor",
          "sex cord stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021657"
    }
  ],
  "children": [
    {
      "id": 4741,
      "label": "ovarian gonadoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11906,
        18316
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3578",
          "GARD:0017100",
          "HP:0000149",
          "MEDGEN:309510",
          "NCIT:C39985",
          "OMIM:424500",
          "Orphanet:206484",
          "SCTID:716594002",
          "UMLS:C1518716",
          "icd11.foundation:1564602847"
        ],
        "synonyms": [
          "GBY",
          "gonadoblastoma",
          "gonadoblastoma of ovary",
          "ovarian gonadoblastoma",
          "ovarian gonadoblastoma (disease)",
          "ovary gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the ovary and is composed of tissues that resemble dysgerminoma or seminoma and are admixed with sex cord tissues. It is found in children or young adults and usually is associated with secondary sex organs abnormalities. The majority of patients present as phenotypic females with virilization. The minority of patients present as phenotypic males with feminization. It typically affects both gonads. If a malignant germ cell component is present, it may metastasize to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002697"
    },
    {
      "id": 19985,
      "label": "maligant granulosa cell tumor of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18316,
        20310,
        21206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019707",
          "MEDGEN:138043",
          "NCIT:C8403",
          "Orphanet:99915",
          "SCTID:254861002",
          "UMLS:C0346175",
          "icd11.foundation:148207042"
        ],
        "synonyms": [
          "adult ovarian granulosa cell tumor",
          "adult ovarian granulosa cell tumour",
          "cancer of granulosa cell",
          "granulosa cell cancer",
          "granulosa cell malignant tumor",
          "granulosa cell malignant tumour",
          "malignant granulosa cell neoplasm",
          "malignant granulosa cell neoplasm of ovary",
          "malignant granulosa cell neoplasm of the ovary",
          "malignant granulosa cell tumor of ovary",
          "malignant granulosa cell tumor of the ovary",
          "malignant granulosa cell tumour of ovary",
          "malignant granulosa cell tumour of the ovary",
          "malignant ovarian granulosa cell neoplasm",
          "malignant ovarian granulosa cell tumor",
          "malignant ovarian granulosa cell tumour",
          "ovarian granulosa cell tumor of adults",
          "ovarian granulosa cell tumour of adults",
          "GCT of the ovary",
          "GTCT",
          "Maligant granulosa cell tumor of the ovary",
          "Maligant granulosa cell tumour of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive granulosa cell tumor that arises from the ovary and metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020541"
    },
    {
      "id": 19986,
      "label": "malignant Sertoli-Leydig cell tumor of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18316,
        22944
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005495",
          "ICD9:239.5",
          "MEDGEN:1825991",
          "Orphanet:99916",
          "SCTID:237795006",
          "UMLS:C5574973"
        ],
        "synonyms": [
          "Androblastoma",
          "Arrhenoblastoma",
          "malignant ovarian Sertoli-Leydig cell tumor",
          "malignant ovarian Sertoli-Leydig cell tumour",
          "ovarian Sertoli-Leydig cell cancer",
          "ovarian Sertoli-Leydig cell tumor, malignant",
          "ovarian malignant Sertoli-Leydig cell tumor",
          "ovarian malignant Sertoli-Leydig cell tumour",
          "ovarian sertoli-Leydig cell tumor, malignant",
          "virilizing ovarian tumor",
          "virilizing ovarian tumour",
          "malignant Sertoli-Leydig cell tumor of the ovary",
          "malignant Sertoli-Leydig cell tumour of the ovary",
          "malignant ovarian sertoli-Leydig cell tumor",
          "malignant ovarian sertoli-Leydig cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant Sertoli-Leydig cell tumor of ovary is a rare malignant sex cord stromal tumor of ovary occurring typically in young women and characterized by manifestations of androgen excess (hirsutism, hair loss, amenorrhea, or oligomenorrhea), when functional."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020542"
    },
    {
      "id": 19987,
      "label": "theca steroid-producing cell malignant tumor of ovary, not further specified",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18316
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019708",
          "MEDGEN:904268",
          "Orphanet:99917",
          "UMLS:C4274494"
        ],
        "synonyms": [
          "theca (steroid-producing) cell cancer, not further specified"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant steroid cell tumor of the ovary, not otherwise specified is a rare malignant sex cord stromal tumor of ovary of unknown histological lineage, occurring in adult women, characterized, in most cases, by manifestations of androgen excess (hirsutism, hair loss, amenorrhea, or oligomenorrhea) and, occasionally, Cushing syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020543"
    }
  ],
  "roots": [
    {
      "id": 18448,
      "label": "malignant non-epithelial tumor of ovary"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor"
    }
  ]
}