{
  "id": 18320,
  "label": "glioblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018177",
  "properties": {
    "xrefs": [
      "DOID:3068",
      "EFO:0000519",
      "GARD:0002491",
      "HP:0012174",
      "HP:0100843",
      "ICDO:9440/3",
      "MEDGEN:42228",
      "MESH:D005909",
      "MedDRA:10018336",
      "MedDRA:10018337",
      "NANDO:2200087",
      "NCIT:C3058",
      "NORD:1187",
      "ONCOTREE:GB",
      "ONCOTREE:GBM",
      "Orphanet:360",
      "SCTID:393563007",
      "UMLS:C0017636"
    ],
    "synonyms": [
      "GBM",
      "GBM (glioblastoma)",
      "WHO grade IV glioma",
      "glioblastoma",
      "glioblastoma (disease)",
      "glioblastoma multiforme",
      "glioblastoma multiforme (disease)",
      "grade IV astrocytic neoplasm",
      "grade IV astrocytic tumor",
      "grade IV astrocytic tumour",
      "grade IV astrocytoma",
      "spongioblastoma multiforme",
      "grade IV adult astrocytic tumor",
      "grade IV adult astrocytic tumour",
      "giant cell glioblastoma (histologic variant)",
      "gliosarcoma (histologic variant)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 17144,
      "label": "high grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020704",
          "MEDGEN:769639",
          "NCIT:C102897",
          "Orphanet:251561",
          "UMLS:C3640999"
        ],
        "synonyms": [
          "high grade astrocytic neoplasm",
          "high grade astrocytic tumor",
          "high-grade astrocytic neoplasm",
          "high-grade astrocytic tumor",
          "high-grade astrocytic tumour",
          "high-grade astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016680"
    }
  ],
  "children": [
    {
      "id": 2919,
      "label": "classical glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050803",
          "GARD:0022771",
          "MEDGEN:820001",
          "NCIT:C111694",
          "UMLS:C3827253"
        ],
        "synonyms": [
          "classical glioblastoma",
          "glioblastoma classical subtype"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000457"
    },
    {
      "id": 2920,
      "label": "proneural glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050804",
          "GARD:0022772",
          "MEDGEN:821212",
          "NCIT:C111692",
          "UMLS:C3828464"
        ],
        "synonyms": [
          "proneural glioblastoma",
          "glioblastoma proneural subtype"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa amplifications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000458"
    },
    {
      "id": 2921,
      "label": "mesenchymal glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050805",
          "GARD:0022773",
          "MEDGEN:821870",
          "NCIT:C111695",
          "UMLS:C3829122"
        ],
        "synonyms": [
          "mesenchymal glioblastoma",
          "glioblastoma mesenchymal subtype"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A molecular subtype of glioblastoma characterized by the presence of NF1 mutations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000459"
    },
    {
      "id": 2922,
      "label": "neural glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050806",
          "GARD:0022774",
          "MEDGEN:821580",
          "NCIT:C111693",
          "UMLS:C3828832"
        ],
        "synonyms": [
          "neural glioblastoma",
          "glioblastoma neural subtype"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A molecular subtype of glioblastoma characterized by the expression of the neural markers NEFL, GABRA1, SYT1, and SLC12A5."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000460"
    },
    {
      "id": 4576,
      "label": "brain glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7155,
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3073",
          "EFO:0006545",
          "GARD:0023150",
          "MEDGEN:138100",
          "NCIT:C4642",
          "SCTID:276828006",
          "UMLS:C0349543"
        ],
        "synonyms": [
          "brain glioblastoma",
          "brain glioblastoma (disease)",
          "brain glioblastoma multiforme",
          "brain glioblastoma multiforme (disease)",
          "glioblastoma multiforme of brain",
          "glioblastoma multiforme of the brain",
          "grade IV astrocytic tumour of brain",
          "grade IV brain astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002501"
    },
    {
      "id": 20099,
      "label": "adult glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6136,
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025213",
          "MEDGEN:124527",
          "NANDO:2200087",
          "NCIT:C9094",
          "UMLS:C0278878"
        ],
        "synonyms": [
          "glioblastoma",
          "adult glioblastoma",
          "adult glioblastoma multiforme",
          "grade IV adult astrocytic neoplasm",
          "grade IV adult astrocytic tumor",
          "grade IV adult astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0020690"
    },
    {
      "id": 25203,
      "label": "IDH-wildtype glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080878",
          "GARD:0026603",
          "NCIT:C39750"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glioblastoma that is characterized by high cellularity, high mitotic activity, necrosis or microvascular proliferation and that lacks mutations in IDH genes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850335"
    }
  ],
  "roots": [
    {
      "id": 17144,
      "label": "high grade astrocytic tumor"
    }
  ]
}