{
  "id": 18336,
  "label": "LMNA-related cardiocutaneous progeria syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018203",
  "properties": {
    "xrefs": [
      "GARD:0021555",
      "MEDGEN:1667690",
      "Orphanet:363618",
      "UMLS:C4750858"
    ],
    "synonyms": [
      "LCPS"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A rare, genetic, premature aging syndrome characterized by adulthood-onset cutaneous manifestations that result in a prematurely aged appearance (i.e. premature thinning and graying of scalp hair, loss of subcutaneous fat, tightening of skin) associated with prominent cardiovascular manifestations, such as accelerated atherosclerosis, calcific valve disease, and cardiomyopathy. Patients present loss of eyebrows and eyelashes in childhood and have a predisposition to develop malignancies."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19146,
      "label": "premature aging syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019017",
          "MEDGEN:65416",
          "MESH:D019588",
          "MedDRA:10063493",
          "Orphanet:79389",
          "UMLS:C0231341"
        ],
        "synonyms": [
          "premature ageing",
          "premature aging"
        ],
        "definition": "Changes in the organism associated with senescence, occurring at an accelerated rate."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019303"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6967
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "hereditary heart disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the cardiovascular system."
      },
      "child_count": 146,
      "reference_id": "MONDO:0100547"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19146,
      "label": "premature aging syndrome"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease"
    }
  ]
}