{
  "id": 18343,
  "label": "Alexander disease type II",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018210",
  "properties": {
    "xrefs": [
      "GARD:0017573",
      "MEDGEN:1842714",
      "NANDO:1200556",
      "Orphanet:363722",
      "UMLS:C5679914"
    ],
    "synonyms": [
      "AxD type II"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Alexander disease type II (AxD type II) is an astrogliopathy and a form of Alexander disease (AxD) characterized by ataxia, bulbar symptoms, spastic paraparesis, palatal myoclonus, and autonomic symptoms."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 10025,
      "label": "Alexander disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18952
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4252",
          "GARD:0005774",
          "MEDGEN:78724",
          "MESH:D038261",
          "NANDO:1200554",
          "NANDO:2200835",
          "NCIT:C84545",
          "NORD:749",
          "OMIM:203450",
          "Orphanet:58",
          "SCTID:81854007",
          "UMLS:C0270726",
          "icd11.foundation:2023359698"
        ],
        "synonyms": [
          "Alexander disease",
          "AxD",
          "ALXDRD",
          "alexanders leukodystrophy",
          "megalencephaly in infancy accompanied by progressive spasticity and dementia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Alexander disease (AxD) is a rare neurodegenerative disorder of the astrocytes comprised of two clinical forms: AxD Type I and Type II manifesting with various degrees of macrocephaly, spasticity, ataxia and seizures and leading to psychomotor regression and death."
      },
      "child_count": 2,
      "reference_id": "MONDO:0008752"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 10025,
      "label": "Alexander disease"
    }
  ]
}