{
  "id": 18348,
  "label": "paraneoplastic neurologic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018215",
  "properties": {
    "xrefs": [
      "GARD:0007326",
      "ICD9:331.89",
      "MEDGEN:155656",
      "MedDRA:10072106",
      "Orphanet:36388",
      "SCTID:192877007",
      "UMLS:C0751911"
    ],
    "synonyms": [
      "PCD",
      "PNS",
      "nervous system paraneoplastic syndrome",
      "paraneoplastic syndrome of nervous system",
      "paraneoplastic cerebellar degeneration"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A paraneoplastic syndrome that involves the nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6799,
      "label": "nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:863",
          "EFO:0000618",
          "ICD10CM:G00-G99",
          "ICD9:349.89",
          "ICD9:349.9",
          "MEDGEN:14336",
          "MESH:D009422",
          "NCIT:C26835",
          "SCTID:118940003",
          "UMLS:C0027765",
          "Wikipedia:Nervous_system_disease"
        ],
        "synonyms": [
          "disease of nervous system",
          "disease or disorder of nervous system",
          "disorder of nervous system",
          "nervous system disease",
          "nervous system disease or disorder",
          "nervous system disorder",
          "neurologic disease",
          "neurologic disorder",
          "neurological disease",
          "neurological disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005071"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        23540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:45320",
          "MESH:D010257",
          "NCIT:C3311",
          "SCTID:49783001",
          "UMLS:C0030472"
        ],
        "synonyms": [
          "paraneoplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021073"
    }
  ],
  "children": [
    {
      "id": 8326,
      "label": "paraneoplastic polyneuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4005,
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8681",
          "GARD:0024499",
          "ICD9:357.3",
          "MEDGEN:124380",
          "MESH:D020364",
          "MedDRA:10062289",
          "NCIT:C3981",
          "SCTID:77659000",
          "UMLS:C0270932"
        ],
        "synonyms": [
          "paraneoplastic polyneuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A diffuse or multifocal peripheral neuropathy caused by the effects of a distant neoplasm. It may be attributed, in part, to the immune response to neoplasm-elaborated proteins. The neuropathy may be sensory, motor, mixed or autonomic. It may be the initial presentation of an occult neoplasm. Detection and resection of the neoplasm may result in cure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006888"
    },
    {
      "id": 16134,
      "label": "opsoclonus-myoclonus syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7073,
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001383",
          "GARD:0010009",
          "ICD9:379.59",
          "MEDGEN:97955",
          "MESH:D053578",
          "MedDRA:10053854",
          "NCIT:C4686",
          "NORD:1527",
          "Orphanet:1183",
          "SCTID:230350000",
          "UMLS:C0393626"
        ],
        "synonyms": [
          "Ataxo-opso-myoclonus syndrome",
          "Kinsbourne syndrome",
          "OMS",
          "Opsoclonus-Myoclonus-Ataxia Syndrome",
          "POMA syndrome",
          "dancing eye syndrome",
          "dancing eye-dancing feet syndrome",
          "oma syndrome",
          "opsoclonus myoclonus syndrome",
          "opsoclonus-myoclonus-ataxia syndrome",
          "paraneoplastic opsoclonus-myoclonus",
          "paraneoplastic opsoclonus-myoclonus-ataxia syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015247"
    },
    {
      "id": 16389,
      "label": "paraneoplastic limbic encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16388,
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025065",
          "ICD9:323.81",
          "NCIT:C4350",
          "Orphanet:163895",
          "SCTID:445014002",
          "icd11.foundation:1147819644"
        ],
        "synonyms": [
          "limbic encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015589"
    },
    {
      "id": 17680,
      "label": "POEMS syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6569,
        16613,
        18348,
        24647,
        24648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14039",
          "EFO:1001115",
          "GARD:0007411",
          "MEDGEN:39276",
          "MESH:D016878",
          "MedDRA:10053869",
          "NANDO:1200033",
          "NCIT:C80303",
          "NORD:1586",
          "Orphanet:2905",
          "SCTID:79268002",
          "UMLS:C0085404",
          "icd11.foundation:1555299114"
        ],
        "synonyms": [
          "Crow-Fukase syndrome",
          "PEP syndrome",
          "POEMS syndrome",
          "Takatsuki syndrome",
          "osteosclerotic myeloma",
          "polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome",
          "polyneuropathy organomegaly",
          "polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017364"
    },
    {
      "id": 18570,
      "label": "Lambert-Eaton myasthenic syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050214",
          "GARD:0006851",
          "ICD9:358.3",
          "MEDGEN:6005",
          "MESH:D015624",
          "MedDRA:10067685",
          "NCIT:C3155",
          "NORD:1346",
          "Orphanet:43393",
          "SCTID:56989000",
          "UMLS:C0022972",
          "icd11.foundation:796417193"
        ],
        "synonyms": [
          "Eaton Lambert syndrome",
          "Eaton-Lambert syndrome",
          "Lambert Eaton myasthenic syndrome",
          "Lambert Eaton syndrome",
          "Lambert-Eaton syndrome",
          "myasthenic syndrome of Lambert-Eaton",
          "myasthenic-myopathic syndrome of Lambert-Eaton"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune, presynaptic disorder of neuromuscular transmission characterized by fluctuating muscle weakness and autonomic dysfunction frequently associated with small-cell lung cancer (SCLC)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018556"
    },
    {
      "id": 18996,
      "label": "cancer-associated retinopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6979,
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018912",
          "ICD9:362.10",
          "MEDGEN:729915",
          "MESH:D059545",
          "Orphanet:71505",
          "SCTID:404663008",
          "UMLS:C1321315",
          "icd11.foundation:1216073790"
        ],
        "synonyms": [
          "CAR syndrome",
          "paraneoplastic retinopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Cancer associated retinopathy (CAR) is a paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019112"
    },
    {
      "id": 23463,
      "label": "paraneoplastic cerebellar degeneration",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18348,
        20940
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022493",
          "MEDGEN:98273",
          "MESH:D020362",
          "NCIT:C4685",
          "Orphanet:623626",
          "UMLS:C0393534",
          "icd11.foundation:1087616692"
        ],
        "synonyms": [
          "paraneoplastic cerebellar degeneration"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, immune-mediated disorder characterized by cerebellar degeneration due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum. Signs and symptoms include progressive ataxia, dysarthria, and nystagmus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044877"
    }
  ],
  "roots": [
    {
      "id": 6799,
      "label": "nervous system disorder"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome"
    }
  ]
}