{
  "id": 18355,
  "label": "ALK-positive large B-cell lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018225",
  "properties": {
    "xrefs": [
      "GARD:0021564",
      "ICDO:9737/3",
      "MEDGEN:232429",
      "NCIT:C7225",
      "Orphanet:364043",
      "SCTID:715950008",
      "UMLS:C1333294",
      "icd11.foundation:2077559619"
    ],
    "synonyms": [
      "ALK+ LBCL",
      "ALK+ large B-cell lymphoma",
      "ALK-DLBCL",
      "ALK-positive large B-cell lymphoma",
      "diffuse large B-cell lymphoma with expression of full-length ALK",
      "diffuse large B-cell lymphoma with expression of full-length anaplastic lymphoma kinase"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma"
    }
  ]
}