{
  "id": 18389,
  "label": "extraskeletal Ewing sarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018270",
  "properties": {
    "xrefs": [
      "DOID:4232",
      "GARD:0017600",
      "MEDGEN:76053",
      "NCIT:C7135",
      "Orphanet:370334",
      "UMLS:C0279980",
      "icd11.foundation:489162074"
    ],
    "synonyms": [
      "EOE",
      "Extra-osseous Ewing's sarcoma",
      "extraosseous Ewing sarcoma",
      "extraosseous Ewing tumor",
      "extraosseous Ewing tumour",
      "extraosseous Ewing's sarcoma",
      "extraosseous Ewing's tumor",
      "extraosseous Ewing's tumour",
      "extraskeletal Ewing sarcoma",
      "extraskeletal Ewing tumor",
      "extraskeletal Ewing tumour",
      "extraskeletal Ewing's sarcoma",
      "extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumour"
    ],
    "definition": "A rare malignant neoplasm of the soft tissues. It is typically a disease of children and young adults. Most commonly occurs in the paravertebral region, chest wall, pelvis and lower extremities. Treatment includes local excision with consideration for post-operative chemotherapy and/or radiotherapy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13857,
      "label": "Ewing sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6816,
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3369",
          "EFO:0000174",
          "GARD:0006390",
          "ICDO:9260/3",
          "MEDGEN:107816",
          "MESH:D012512",
          "MedDRA:10015560",
          "NANDO:2200053",
          "NCIT:C4817",
          "OMIM:612219",
          "ONCOTREE:ES",
          "Orphanet:319",
          "UMLS:C0553580",
          "icd11.foundation:458106328"
        ],
        "synonyms": [
          "ES",
          "Ewing sarcoma",
          "Ewing's family localised tumour",
          "Ewing's sarcoma",
          "Ewing's tumor",
          "Ewing's tumour",
          "Ewing tumor",
          "Ewing tumour",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumour",
          "Ewings sarcoma-primitive neuroectodermal tumor",
          "Ewings sarcoma-primitive neuroectodermal tumour",
          "localised Ewing sarcoma",
          "localised Ewing's sarcoma",
          "localised Ewing's sarcoma/peripheral primitive neuroectodermal tumour",
          "localised Ewing's tumour",
          "localised peripheral primitive neuroectodermal tumour",
          "localized Ewing sarcoma",
          "localized Ewing's sarcoma",
          "localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor",
          "localized Ewing's tumor",
          "localized peripheral primitive neuroectodermal tumor",
          "neuroepithelioma",
          "neuroepithelioma, peripheral",
          "peripheral primitive neuroectodermal tumour",
          "sarcoma, Ewing's"
        ],
        "definition": "A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0012817"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070663",
          "EFO:1001968",
          "GARD:0004898",
          "MEDGEN:1642116",
          "NCIT:C9306",
          "NORD:1953",
          "Orphanet:3394",
          "SCTID:424952003",
          "UMLS:C4551687"
        ],
        "synonyms": [
          "malignant soft tissue tumor",
          "malignant soft tissue tumour",
          "connective tissue sarcoma",
          "malignant mesenchymal tumor",
          "malignant mesenchymal tumour",
          "non-Rhabdo. soft tissue sarcoma",
          "sarcoma of soft tissue",
          "sarcoma of the soft tissue",
          "soft part sarcoma",
          "soft tissue sarcoma"
        ],
        "definition": "A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones."
      },
      "child_count": 92,
      "reference_id": "MONDO:0018078"
    },
    {
      "id": 20284,
      "label": "extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4985",
          "EFO:1000250",
          "MEDGEN:232170",
          "NCIT:C27293",
          "UMLS:C1333514"
        ],
        "synonyms": [
          "extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor",
          "extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumour",
          "extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumor",
          "extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumour",
          "extraosseous Ewings sarcoma-primitive neuroepithelial tumor",
          "extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor",
          "extraosseous Ewing's tumor",
          "extraosseous Ewing's tumour"
        ],
        "definition": "A spectrum of malignant tumors arising from the soft tissues, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021039"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13857,
      "label": "Ewing sarcoma"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma"
    },
    {
      "id": 20284,
      "label": "extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor"
    }
  ]
}