{
  "id": 18398,
  "label": "multicentric osteolysis-nodulosis-arthropathy spectrum",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018298",
  "properties": {
    "xrefs": [
      "GARD:0017610",
      "MEDGEN:342428",
      "Orphanet:371428",
      "SCTID:716868003",
      "UMLS:C1850155"
    ],
    "synonyms": [
      "MONA spectrum"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A rare genetic chronic skeletal disorder characterized by peripheral osteolysis (especially carpal and tarsal bones), interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 19478,
      "label": "primary osteolysis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019204",
          "MEDGEN:1843089",
          "Orphanet:93449",
          "UMLS:C5559806",
          "icd11.foundation:285636466"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 14,
      "reference_id": "MONDO:0019707"
    }
  ],
  "children": [
    {
      "id": 11018,
      "label": "multicentric osteolysis, nodulosis, and arthropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        18398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013743",
          "NCIT:C123437",
          "OMIM:259600"
        ],
        "synonyms": [
          "Al-Aqeel Sewairi syndrome",
          "MONA",
          "MONA, MMP2-related",
          "NAO syndrome",
          "Torg syndrome",
          "Winchester-Torg syndrome",
          "multicentric osteolysis, nodulosis and arthropathy, MMP2-related",
          "multicentric osteolysis, nodulosis, and arthropathy",
          "nodulosis-arthropathy-osteolysis syndrome",
          "osteolysis, hereditary multicentric",
          "Torg-Winchester syndrome",
          "Torg-Winchester syndrome, formerly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A rare, autosomal recessive inherited syndrome caused by mutations in the MMP2 gene. It is characterized by the presence of multiple, painless subcutaneous nodules, osteolysis particularly in the hands and feet, osteoporosis, and arthropathy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009809"
    },
    {
      "id": 11382,
      "label": "Winchester syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080696",
          "GARD:0007894",
          "ICD9:733.29",
          "MEDGEN:98152",
          "MESH:C536709",
          "NCIT:C170731",
          "NORD:1857",
          "OMIM:277950",
          "SCTID:254151006",
          "UMLS:C0432289"
        ],
        "synonyms": [
          "MMP14-related multicentric osteolysis, nodulosis, and arthropathy",
          "MONA, MMP14-related",
          "WNCHRS",
          "Winchester syndrome",
          "multicentric osteolysis, nodulosis and arthropathy, MMP14-related",
          "Al-Qeel Sewairi syndrome",
          "NOA syndrome",
          "multicentric osteolysis, nodulosis and arthropathy",
          "nodulosis arthropathy osteolysis syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010201"
    }
  ],
  "roots": [
    {
      "id": 19478,
      "label": "primary osteolysis"
    }
  ]
}