{
  "id": 18407,
  "label": "Langerhans cell histiocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018310",
  "properties": {
    "xrefs": [
      "DOID:2571",
      "EFO:1000318",
      "GARD:0006858",
      "ICD9:202.5",
      "ICD9:277.89",
      "ICDO:9751/1",
      "ICDO:9751/3",
      "ICDO:9752/1",
      "ICDO:9753/1",
      "ICDO:9754/3",
      "MEDGEN:5568",
      "MedDRA:10069698",
      "NANDO:2200031",
      "NCIT:C3107",
      "NORD:1348",
      "OMIM:604856",
      "ONCOTREE:LCH",
      "Orphanet:389",
      "SCTID:65399007",
      "UMLS:C0019621",
      "icd11.foundation:1388720498",
      "icd11.foundation:216625985"
    ],
    "synonyms": [
      "LCH",
      "Langerhans cell granulomatosis",
      "Langerhans cell histiocytosis",
      "Langerhans cell histiocytosis, NOS",
      "Langerhans cell histiocytosis, Not otherwise specified",
      "histiocytosis X",
      "Langerhans-cell histiocytosis",
      "Lch"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4688,
      "label": "histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3405",
          "MEDGEN:6845",
          "MESH:D015614",
          "NANDO:2100005",
          "NCIT:C3106",
          "ONCOTREE:HDCN",
          "UMLS:C0019618"
        ],
        "synonyms": [
          "histiocytic infiltrate",
          "histiocytic syndrome",
          "histiocytic and dendritic cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes."
      },
      "child_count": 5,
      "reference_id": "MONDO:0002637"
    },
    {
      "id": 6569,
      "label": "leukocyte disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9500",
          "ICD9:288",
          "ICD9:288.9",
          "MEDGEN:7325",
          "MESH:D007960",
          "SCTID:54097007",
          "UMLS:C0023510"
        ],
        "synonyms": [
          "disease of leukocyte",
          "disease or disorder of leukocyte",
          "disorder of leukocyte",
          "disorder, leukocyte",
          "disorders, leukocyte",
          "leukocyte disease",
          "leukocyte disease or disorder",
          "leukocyte disorder",
          "white blood cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving leukocytes."
      },
      "child_count": 46,
      "reference_id": "MONDO:0004805"
    },
    {
      "id": 19729,
      "label": "dendritic cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7797
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008317",
          "MEDGEN:1842732",
          "Orphanet:98289",
          "SCTID:737223000",
          "UMLS:C5681852"
        ],
        "synonyms": [
          "dendritic cell sarcoma, NOS",
          "dendritic cell sarcoma, Not otherwise specified",
          "dendritic cell tumor, NOS",
          "dendritic cell tumor, not otherwise specified",
          "dendritic cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A dendritic cell tumor develops from the cells of the immune system. This condition typically begins in the lymph system and may spread to nearby organs or distant parts of the body (metastasize). The symptoms and severity of the condition depend on the subtype and location of the tumor."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020082"
    },
    {
      "id": 21541,
      "label": "phagocytic cell dysfunction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:585044",
          "SCTID:302874002",
          "UMLS:C0398732"
        ],
        "synonyms": [
          "defective phagocytosis",
          "phagocytic cell dysfunction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0024627"
    }
  ],
  "children": [
    {
      "id": 17420,
      "label": "Langerhans cell histiocytosis specific to childhood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025085",
          "MEDGEN:859249",
          "NANDO:2200031",
          "NCIT:C114483",
          "Orphanet:264724",
          "UMLS:C3899655"
        ],
        "synonyms": [
          "Langerhans cell histiocytosis",
          "Langerhans cell granulomatosis specific to childhood",
          "childhood Langerhans cell histiocytosis",
          "histiocytosis X specific to childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis that occurs during childhood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017025"
    },
    {
      "id": 17422,
      "label": "Langerhans cell histiocytosis specific to adulthood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17421,
        18407,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025086",
          "MEDGEN:859694",
          "NANDO:2200031",
          "NCIT:C114929",
          "Orphanet:264750",
          "UMLS:C3900100"
        ],
        "synonyms": [
          "Langerhans cell histiocytosis",
          "Langerhans cell granulomatosis specific to adulthood",
          "adult Langerhans cell histiocytosis",
          "histiocytosis X specific to adulthood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis that occurs during adulthood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0017029"
    },
    {
      "id": 19966,
      "label": "eosinophilic granuloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6815,
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025166",
          "ICD9:277.89",
          "ICDO:9752/1",
          "MEDGEN:4979",
          "MESH:D004803",
          "MedDRA:10014956",
          "NCIT:C3016",
          "Orphanet:99871",
          "SCTID:129000002",
          "UMLS:C0014461",
          "icd11.foundation:1377407737"
        ],
        "synonyms": [
          "Monostotic Langerhans cell histiocytosis",
          "chronic and localised Langerhans cell histiocytosis",
          "chronic and localized Langerhans cell histiocytosis",
          "chronic unifocal Langerhans cell histiocytosis",
          "eosinophilic granuloma",
          "eosinophilic xanthomatous granuloma",
          "unifocal Langerhans cell histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clinical variant of Langerhans cell histiocytosis characterized by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterized by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophils, neutrophils, and small, mature lymphocytes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020517"
    },
    {
      "id": 19968,
      "label": "hand-Schuller-Christian disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006567",
          "ICD9:277.89",
          "ICDO:9753/1",
          "MEDGEN:1804593",
          "NCIT:C6920",
          "Orphanet:99873",
          "SCTID:39795003",
          "UMLS:C5574737"
        ],
        "synonyms": [
          "chronic multifocal Langerhans cell histiocytosis",
          "classic multifocal Langerhans cell histiocytosis",
          "hand-SChüller-Christian disease",
          "hand-Schuller-Christian disease",
          "multifocal Unisystem Langerhans cell histiocytosis",
          "multifocal eosinophilic granuloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020519"
    },
    {
      "id": 26162,
      "label": "unifocal langerhans cell histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027417",
          "MEDGEN:727088",
          "Orphanet:687730",
          "UMLS:C1306599"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975906"
    },
    {
      "id": 26163,
      "label": "pulmonary langerhans cell histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027418",
          "MEDGEN:264101",
          "Orphanet:687733",
          "UMLS:C1455705"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975907"
    },
    {
      "id": 26164,
      "label": "single-system multifocal langerhans cell histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027419",
          "MEDGEN:1876610",
          "Orphanet:687738",
          "UMLS:C6012359"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975908"
    },
    {
      "id": 26165,
      "label": "multisystem langerhans cell histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18407
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027420",
          "MEDGEN:1876606",
          "Orphanet:687741",
          "UMLS:C6012358"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975909"
    }
  ],
  "roots": [
    {
      "id": 4688,
      "label": "histiocytosis"
    },
    {
      "id": 6569,
      "label": "leukocyte disorder"
    },
    {
      "id": 19729,
      "label": "dendritic cell tumor"
    },
    {
      "id": 21541,
      "label": "phagocytic cell dysfunction"
    }
  ]
}