{
  "id": 18424,
  "label": "mucinous adenocarcinoma of the appendix",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018330",
  "properties": {
    "xrefs": [
      "GARD:0021629",
      "MEDGEN:317382",
      "NCIT:C43558",
      "ONCOTREE:MAAP",
      "Orphanet:391723",
      "UMLS:C1706832",
      "icd11.foundation:425095558"
    ],
    "synonyms": [
      "appendiceal mucinous adenocarcinoma",
      "appendix mucinous adenocarcinoma",
      "vermiform appendix mucinous adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Mucinous adenocarcinoma of the appendix is a very rare, slow growing, well-differentiated epithelial neoplasm of the appendix characterized by abundant mucin production. Clinically, it presents as acute appendicitis (with abdominal pain, fever, leukocytosis) or as pseudomyxoma peritonei (wide-spread presence of mucin within the peritoneal cavity), however some patients may be completely asymptomatic at the time of diagnosis. In many cases, a second gastrointestinal malignancy is present."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6745,
      "label": "colon mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4386,
        6700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3029",
          "EFO:0000364",
          "MEDGEN:76007",
          "NCIT:C7966",
          "UMLS:C0279639"
        ],
        "synonyms": [
          "colloid adenocarcinoma of colon",
          "colloid adenocarcinoma of the colon",
          "colloid colon adenocarcinoma",
          "colloidal adenocarcinoma of colon",
          "colloidal adenocarcinoma of the colon",
          "colloidal colon adenocarcinoma",
          "colon colloid adenocarcinoma",
          "colon colloidal adenocarcinoma",
          "colon mucinous adenocarcinoma",
          "colonic colloid adenocarcinoma",
          "colonic colloidal adenocarcinoma",
          "colonic mucinous adenocarcinoma",
          "mucinous adenocarcinoma of colon",
          "mucinous adenocarcinoma of the colon",
          "mucinous colon adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the colon characterized by the presence of pools of extracellular mucin. Malignant glandular epithelial cells are present in the mucin collections. Mucin constitutes more than 50% of the lesion."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005007"
    },
    {
      "id": 7662,
      "label": "appendix adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5155,
        7614
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3608",
          "EFO:1000088",
          "GARD:0010564",
          "MEDGEN:65942",
          "NCIT:C7718",
          "ONCOTREE:APAD",
          "SCTID:413445002",
          "UMLS:C0238003",
          "icd11.foundation:1696330825"
        ],
        "synonyms": [
          "adenocarcinoma of appendix",
          "adenocarcinoma of the appendix",
          "appendiceal adenocarcinoma",
          "appendix adenocarcinoma",
          "vermiform appendix adenocarcinoma",
          "APAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the vermiform appendix."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006087"
    }
  ],
  "children": [
    {
      "id": 4745,
      "label": "appendix mucinous cystadenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7469,
        18424
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3607",
          "GARD:0023218",
          "MEDGEN:204256",
          "NCIT:C5511",
          "UMLS:C1096639"
        ],
        "synonyms": [
          "appendiceal colloid cystadenocarcinoma",
          "appendiceal colloidal cystadenocarcinoma",
          "appendiceal mucinous cystadenocarcinoma",
          "appendix colloid cystadenocarcinoma",
          "appendix colloidal cystadenocarcinoma",
          "appendix mucinous cystadenocarcinoma",
          "colloid cystadenocarcinoma of appendix",
          "colloid cystadenocarcinoma of the appendix",
          "colloidal cystadenocarcinoma of appendix",
          "colloidal cystadenocarcinoma of the appendix",
          "mucinous cystadenocarcinoma of appendix",
          "mucinous cystadenocarcinoma of the appendix",
          "vermiform appendix mucinous cystadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation and cystic structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002703"
    },
    {
      "id": 17431,
      "label": "pseudomyxoma peritonei",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4249,
        18424,
        24710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3559",
          "GARD:0007488",
          "ICDO:8480/6",
          "MEDGEN:18726",
          "MESH:D011553",
          "MedDRA:10037138",
          "NCIT:C3345",
          "NORD:1628",
          "Orphanet:26790",
          "SCTID:307601000",
          "UMLS:C0033822",
          "icd11.foundation:1849365560"
        ],
        "synonyms": [
          "Adenomucinosis",
          "Myxoma peritonei",
          "PMP",
          "gelatinous ascites",
          "mucinous ascites",
          "peritoneal cavity pseudomyxoma peritonei",
          "pseudomyxoma peritonei",
          "pseudomyxoma peritonei (morphologic abnormality)",
          "well differentiated peritoneal mucinous adenocarcinoma",
          "syndrome of pseudomyxoma peritonei"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Pseudomyxoma peritonei is characterized by disseminated intra-peritoneal mucinous tumors and mucinous ascites in the abdomen and pelvis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017048"
    }
  ],
  "roots": [
    {
      "id": 6745,
      "label": "colon mucinous adenocarcinoma"
    },
    {
      "id": 7662,
      "label": "appendix adenocarcinoma"
    }
  ]
}