{
  "id": 18435,
  "label": "squamous cell carcinoma of penis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018352",
  "properties": {
    "xrefs": [
      "DOID:5518",
      "GARD:0021639",
      "MEDGEN:116057",
      "NCIT:C7729",
      "ONCOTREE:PSCC",
      "Orphanet:398058",
      "SCTID:403468003",
      "UMLS:C0238348",
      "icd11.foundation:186592209"
    ],
    "synonyms": [
      "epidermoid carcinoma of penis",
      "epidermoid carcinoma of the penis",
      "epidermoid cell carcinoma of penis",
      "epidermoid cell carcinoma of the penis",
      "penile epidermoid carcinoma",
      "penile epidermoid cell carcinoma",
      "penile squamous car.(epidermoid)",
      "penile squamous carcinoma (epidermoid)",
      "penile squamous cell cancer",
      "penile squamous cell carcinoma",
      "penis squamous cell carcinoma",
      "squamous cell carcinoma of penis",
      "squamous cell carcinoma of the penis",
      "PSCC"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 7886,
      "label": "penile carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3554,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3449",
          "EFO:1000465",
          "GARD:0024383",
          "MEDGEN:208877",
          "NCIT:C9061",
          "SCTID:372106005",
          "UMLS:C0853105"
        ],
        "synonyms": [
          "cancer of penis",
          "cancer of the penis",
          "cancer penis",
          "penile cancer",
          "carcinoma of penis",
          "carcinoma of the penis",
          "penile carcinoma",
          "penis carcinoma",
          "penile cancer, adult"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the penis"
      },
      "child_count": 6,
      "reference_id": "MONDO:0006360"
    }
  ],
  "children": [
    {
      "id": 6219,
      "label": "sarcomatoid penile squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18435,
        20715
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7958",
          "GARD:0023988",
          "MEDGEN:235580",
          "NCIT:C6984",
          "UMLS:C1335923"
        ],
        "synonyms": [
          "sarcomatoid carcinoma of the penis",
          "sarcomatoid penile carcinoma",
          "sarcomatoid penile squamous cell carcinoma",
          "sarcomatous carcinoma of the penis",
          "spindle cell carcinoma of the penis",
          "squamous cell carcinoma of penis, sarcomatoid type",
          "squamous cell carcinoma of the penis, sarcomatoid type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis and is characterized by the presence of malignant spindle-shaped cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004410"
    },
    {
      "id": 6238,
      "label": "penis mixed squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8009",
          "GARD:0024000",
          "MEDGEN:268711",
          "NCIT:C39959",
          "UMLS:C1513369"
        ],
        "synonyms": [
          "mixed squamous cell carcinoma of the penis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis and is characterized by a mixture of morphologic patterns (e.g., high grade squamous cell carcinoma and verrucous carcinoma or warty-basaloid carcinoma)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004430"
    },
    {
      "id": 6241,
      "label": "papillary carcinoma of the penis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4983,
        18435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8013",
          "GARD:0024002",
          "MEDGEN:235455",
          "NCIT:C6983",
          "UMLS:C1335322"
        ],
        "synonyms": [
          "papillary carcinoma of penis",
          "papillary carcinoma of the penis",
          "papillary penile carcinoma",
          "papillary penile squamous carcinoma",
          "papillary squamous carcinoma of penis",
          "papillary squamous carcinoma of the penis",
          "penis papillary carcinoma",
          "squamous carcinoma of penis, papillary type",
          "squamous carcinoma of the penis, papillary type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis and is characterized by the presence of a papillary growth pattern."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004433"
    },
    {
      "id": 6455,
      "label": "penis carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6473,
        18435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8872",
          "GARD:0024082",
          "ICD10CM:D07.4",
          "ICD9:233.5",
          "ICDO:8080/2",
          "MEDGEN:102309",
          "NCIT:C27790",
          "SCTID:398831006",
          "UMLS:C0154089"
        ],
        "synonyms": [
          "Bowen disease of the penis",
          "Bowen's disease of penis",
          "Bowen's disease of the penis",
          "Queyrat erythroplasia",
          "Queyrat's erythroplasia",
          "carcinoma in situ of penis",
          "carcinoma in situ of the penis",
          "erythroplasia of Queyrat",
          "grade III penile intraepithelial neoplasia",
          "grade III squamous intraepithelial lesion of penis",
          "grade III squamous intraepithelial lesion of the penis",
          "penile carcinoma in situ",
          "penile carcinoma in situ aJCC v7",
          "penis in situ carcinoma",
          "stage 0 penile carcinoma in situ",
          "stage 0 penis carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the penis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004671"
    },
    {
      "id": 20070,
      "label": "human papillomavirus-related penile squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18435,
        20071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025200",
          "MEDGEN:235178",
          "NCIT:C27682",
          "UMLS:C1334056"
        ],
        "synonyms": [
          "HPV-related penile squamous cell carcinoma",
          "human papilloma virus related penile squamous cell carcinoma",
          "human papilloma virus-related penile squamous cell carcinoma",
          "human papillomavirus-related penile squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the penis and is caused by human papillomavirus infection. Morphologic variants include basaloid carcinoma and warty carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020656"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 7886,
      "label": "penile carcinoma"
    }
  ]
}