{ "id": 18447, "label": "malignant epithelial tumor of ovary", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0018364", "properties": { "xrefs": [ "DOID:2151", "GARD:0009362", "MEDGEN:577291", "MESH:C538090", "NCIT:C40026", "Orphanet:398934", "SCTID:254849005", "UMLS:C0346161" ], "synonyms": [ "epithelial cancer of ovary", "malignant ovarian epithelial tumor", "malignant ovarian epithelial tumour", "malignant ovarian surface epithelial-stromal neoplasm", "malignant ovarian surface epithelial-stromal tumor", "malignant ovarian surface epithelial-stromal tumour", "ovarian epithelial cancer", "ovarian epithelial tumor, malignant", "ovarian malignant epithelial tumor", "ovarian malignant epithelial tumour", "ovarian stromal cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor." }, "isLeaf": false, "isRoot": false, "child_count": 6, "parents": [ { "id": 4347, "label": "ovarian epithelial tumor", "isLeaf": false, "isRoot": false, "parents": [ 7265, 20309 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2152", "ICD9:239.5", "MEDGEN:90969", "NCIT:C4381", "ONCOTREE:OVT", "SCTID:237057005", "UMLS:C0341823" ], "synonyms": [ "epithelial neoplasm of ovary", "epithelial neoplasm of the ovary", "epithelial tumor of ovary", "epithelial tumor of the ovary", "epithelial tumour of ovary", "epithelial tumour of the ovary", "ovarian epithelial tumor", "ovarian surface epithelial-stromal tumor", "ovarian surface epithelial-stromal tumour", "ovarian surface-epithelial stromal neoplasm", "ovary epithelial neoplasm", "OVT", "ovary epithelial cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor." }, "child_count": 22, "reference_id": "MONDO:0002229" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" }, { "id": 9481, "label": "ovarian cancer", "isLeaf": false, "isRoot": false, "parents": [ 3637, 20309 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2394", "ICD10CM:C56", "ICD9:183.0", "MEDGEN:216027", "MESH:D010051", "NCIT:C7431", "OMIM:167000", "Orphanet:213500", "SCTID:363443007", "UMLS:C1140680", "icd11.foundation:685124533" ], "synonyms": [ "ovarian neoplasm", "ovary neoplasm", "tumor of the ovary", "tumour of the ovary", "cancer of ovary", "cancer of the ovary", "malignant neoplasm of ovary", "malignant neoplasm of the ovary", "malignant ovarian neoplasm", "malignant ovarian tumor", "malignant ovarian tumour", "malignant ovary neoplasm", "malignant tumor of ovary", "malignant tumor of the ovary", "malignant tumour of ovary", "malignant tumour of the ovary", "ovarian cancer", "ovarian cancer, somatic", "ovarian malignant tumor", "ovarian malignant tumour", "ovary cancer", "ovarian cancer, epithelial", "primary ovarian cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, "child_count": 22, "reference_id": "MONDO:0008170" } ], "children": [ { "id": 2987, "label": "ovarian clear cell cancer", "isLeaf": false, "isRoot": false, "parents": [ 18447, 20381 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050934", "GARD:0022799", "MEDGEN:276544", "NCIT:C40077", "UMLS:C1518230" ], "synonyms": [ "malignant ovarian clear cell neoplasm", "malignant ovarian clear cell tumor", "malignant ovarian clear cell tumour", "ovarian clear cell carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An invasive malignant neoplasm that arises from the ovary and is characterized by a predominance of clear and hobnail malignant epithelial cells." }, "child_count": 4, "reference_id": "MONDO:0000548" }, { "id": 4927, "label": "malignant ovarian Brenner tumor", "isLeaf": true, "isRoot": false, "parents": [ 4468, 18447 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4217", "GARD:0023301", "ICDO:9000/3", "MEDGEN:90793", "NCIT:C4270", "UMLS:C0334495" ], "synonyms": [ "malignant Brenner tumor of ovary", "malignant Brenner tumor of the ovary", "malignant Brenner tumour of ovary", "malignant Brenner tumour of the ovary", "malignant ovarian Brenner tumor", "ovarian Brenner tumor, malignant" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant neoplasm that arises from the ovary and is characterized by the presence of an invasive malignant transitional cell component and nests of benign transitional cells in a fibrotic stroma. When the neoplasm is confined to the ovary, the prognosis is good." }, "child_count": 0, "reference_id": "MONDO:0002920" }, { "id": 5685, "label": "ovarian endometrial cancer", "isLeaf": false, "isRoot": false, "parents": [ 4560, 18447 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6212", "GARD:0023680", "MEDGEN:276545", "NCIT:C40051", "UMLS:C1518231" ], "synonyms": [ "endometrioid tumor of ovary", "endometrioid tumour of ovary", "malignant ovarian endometrioid tumor", "malignant ovarian endometrioid tumour", "ovary endometrioid tumor", "ovary endometrioid tumour", "ovary female reproductive endometrioid cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells." }, "child_count": 4, "reference_id": "MONDO:0003812" }, { "id": 6864, "label": "ovarian carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 18447 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4001", "EFO:0001075", "GARD:0024154", "MEDGEN:1648335", "NCIT:C4908", "UMLS:C4721610" ], "synonyms": [ "ovarian cancer", "ovarian epithelial cancer", "carcinoma of ovary", "carcinoma of the ovary", "epithelial ovarian cancer", "ovarian carcinoma", "ovary carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002" }, "child_count": 9, "reference_id": "MONDO:0005140" }, { "id": 21318, "label": "mucinous ovarian cancer", "isLeaf": false, "isRoot": false, "parents": [ 5636, 18447 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025380", "MEDGEN:274767", "NCIT:C40033", "ONCOTREE:MOV", "UMLS:C1518233" ], "synonyms": [ "malignant ovarian mucinous neoplasm", "malignant ovarian mucinous tumor", "malignant ovarian mucinous tumour", "ovarian mucinous neoplasm, malignant" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract. It includes mucinous adenocarcinoma and mucinous adenocarcinofibroma." }, "child_count": 4, "reference_id": "MONDO:0024282" }, { "id": 21609, "label": "malignant ovarian serous tumor", "isLeaf": false, "isRoot": false, "parents": [ 18447, 22963 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025472", "MEDGEN:309396", "NCIT:C40025", "UMLS:C1518234" ], "synonyms": [ "malignant ovarian serous tumor", "ovarian serous tumor, malignant" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. It includes serous adenocarcinoma and serous adenocarcinofibroma." }, "child_count": 2, "reference_id": "MONDO:0024885" } ], "roots": [ { "id": 4347, "label": "ovarian epithelial tumor" }, { "id": 6734, "label": "carcinoma" }, { "id": 9481, "label": "ovarian cancer" } ] }