{
  "id": 18450,
  "label": "immature ovarian teratoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018369",
  "properties": {
    "xrefs": [
      "DOID:6331",
      "GARD:0021654",
      "MEDGEN:138044",
      "NCIT:C39995",
      "NCIT:C8111",
      "ONCOTREE:OIMT",
      "Orphanet:398987",
      "SCTID:254871000",
      "UMLS:C0346182",
      "icd11.foundation:551209361"
    ],
    "synonyms": [
      "immature germ cell teratoma of ovary",
      "immature germ cell teratoma of the ovary",
      "immature ovarian teratoma",
      "immature teratoma of ovary",
      "immature teratoma of the ovary",
      "malignant germ cell teratoma of ovary",
      "malignant germ cell teratoma of the ovary",
      "malignant ovarian germ cell teratoma",
      "malignant ovarian teratoma",
      "malignant teratoma of ovary",
      "malignant teratoma of the ovary",
      "ovarian germ cell immature teratoma",
      "ovarian immature germ cell teratoma",
      "ovarian immature teratoma",
      "ovarian malignant teratoma",
      "ovary malignant teratoma",
      "immature teratoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5427,
      "label": "malignant teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4656,
        7832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5563",
          "GARD:0023541",
          "MEDGEN:1652407",
          "NCIT:C4287",
          "UMLS:C4722083"
        ],
        "synonyms": [
          "teratoma, malignant",
          "malignant extragonadal teratoma"
        ],
        "definition": "A malignant form of teratoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003514"
    },
    {
      "id": 5691,
      "label": "ovarian biphasic or triphasic teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7245
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6232",
          "GARD:0023684",
          "MEDGEN:274086",
          "NCIT:C39992",
          "UMLS:C1518691"
        ],
        "synonyms": [
          "ovarian biphasic or triphasic teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor that arises from the ovary and is composed of tissues that originate from two or three of the following germ layers, endoderm, ectoderm, or mesoderm."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003821"
    },
    {
      "id": 16723,
      "label": "malignant non-dysgerminomatous germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5339,
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020349",
          "MEDGEN:1826164",
          "NCIT:C102870",
          "Orphanet:206538",
          "UMLS:C5679783"
        ],
        "synonyms": [
          "non-dysgerminomatous germ cell cancer of ovary",
          "ovarian Nondysgerminomatous germ cell tumor",
          "ovarian Nondysgerminomatous germ cell tumour",
          "ovarian non-dysgerminomatous germ cell tumor",
          "ovarian non-dysgerminomatous germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor other than dysgerminoma that arises from the ovary."
      },
      "child_count": 10,
      "reference_id": "MONDO:0016096"
    }
  ],
  "children": [
    {
      "id": 5270,
      "label": "malignant struma ovarii",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7952,
        8405,
        18450
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5208",
          "GARD:0023454",
          "ICDO:9090/3",
          "MEDGEN:137777",
          "NCIT:C4291",
          "UMLS:C0334525"
        ],
        "synonyms": [
          "struma ovarii, malignant",
          "struma ovarii, malignant (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An ovarian mature teratoma characterized by the presence of aberrant thyroid tissue with morphologic changes identical to thyroid carcinoma. Patients may present with abdominal mass and unusual symptoms due to thyrotoxicosis, or with Meigs syndrome (ascites and pleural effusion)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003332"
    },
    {
      "id": 5918,
      "label": "childhood immature teratoma of ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5689,
        6283,
        18450,
        20015
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7037",
          "GARD:0023809",
          "MEDGEN:232353",
          "NCIT:C6547",
          "UMLS:C1332990"
        ],
        "synonyms": [
          "childhood immature ovarian teratoma",
          "childhood immature teratoma of the ovary",
          "childhood ovarian immature teratoma",
          "immature ovarian teratoma of childhood",
          "paediatric immature ovarian teratoma",
          "paediatric immature teratoma of ovary",
          "paediatric immature teratoma of the ovary",
          "paediatric ovarian immature teratoma",
          "pediatric immature ovarian teratoma",
          "pediatric immature teratoma of ovary",
          "pediatric immature teratoma of the ovary",
          "pediatric ovarian immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An immature teratoma that arises from the ovary and occurs in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004082"
    }
  ],
  "roots": [
    {
      "id": 5427,
      "label": "malignant teratoma"
    },
    {
      "id": 5691,
      "label": "ovarian biphasic or triphasic teratoma"
    },
    {
      "id": 16723,
      "label": "malignant non-dysgerminomatous germ cell tumor of ovary"
    }
  ]
}