{
  "id": 18454,
  "label": "secondary avascular necrosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018374",
  "properties": {
    "xrefs": [
      "GARD:0021659",
      "MEDGEN:1842971",
      "Orphanet:399169",
      "UMLS:C5680036"
    ],
    "synonyms": [
      "secondary AVN"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 18453,
      "label": "avascular necrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7060
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021658",
          "MEDGEN:10200",
          "NCIT:C34841",
          "Orphanet:399164",
          "SCTID:397758007",
          "UMLS:C0027543"
        ],
        "synonyms": [
          "AVN",
          "avascular necrosis of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018373"
    }
  ],
  "children": [
    {
      "id": 10506,
      "label": "Gaucher disease type I",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16880,
        18295,
        18454,
        18462,
        19753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110957",
          "GARD:0002441",
          "MEDGEN:409531",
          "NANDO:1200057",
          "NANDO:2201210",
          "OMIM:230800",
          "Orphanet:77259",
          "SCTID:62201009",
          "UMLS:C1961835"
        ],
        "synonyms": [
          "Gaucher disease type I",
          "Gaucher disease, noncerebral juvenile",
          "Gaucher's disease type I",
          "Gba deficiency",
          "acid Beta-glucosidase deficiency",
          "non-cerebral juvenile Gaucher disease",
          "Gaucher disease type 1",
          "Gaucher disease, type 1",
          "Gaucher disease, type I",
          "Gd 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Gaucher disease type 1 is the chronic non-neurological form of Gaucher disease (GD) characterized by organomegaly, bone involvement and cytopenia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009265"
    },
    {
      "id": 14179,
      "label": "hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18454,
        18462,
        23980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111903",
          "GARD:0017125",
          "MEDGEN:416465",
          "MESH:C567737",
          "OMIM:613116",
          "Orphanet:217467",
          "UMLS:C2751090",
          "icd11.foundation:1764310021"
        ],
        "synonyms": [
          "hereditary thrombophilia due to congenital HRG deficiency",
          "thrombophilia 11 due to HRG deficiency",
          "THPH11",
          "thrombophilia due to elevated histidine-rich glycoprotein",
          "thrombophilia due to histidine-rich glycoprotein deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013143"
    },
    {
      "id": 14180,
      "label": "hereditary antithrombin deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18454,
        18462,
        23980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3755",
          "GARD:0006148",
          "ICD9:286.9",
          "MEDGEN:75781",
          "MESH:D020152",
          "NORD:791",
          "OMIM:613118",
          "Orphanet:82",
          "SCTID:36351005",
          "UMLS:C0272375"
        ],
        "synonyms": [
          "AT3D",
          "Antithrombin Deficiency",
          "antithrombin 3 deficiency",
          "antithrombin III deficiency",
          "congenital AT-III deficiency",
          "congenital antithrombin III deficiency",
          "hereditary antithrombin deficiency",
          "hereditary thrombophilia due to congenital antithrombin 3 deficiency",
          "hereditary thrombophilia due to congenital antithrombin deficiency",
          "inherited antithrombin deficiency",
          "thrombophilia 7 due to antithrombin III deficiency",
          "thrombophilia due to antithrombin 3 deficiency",
          "thrombophilia due to antithrombin III deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, genetic, hematological disease characterized by decreased levels of antithrombin activity in plasma resulting in impaired inactivation of thrombin and factor Xa. Patients have an increased risk for venous thromboembolism, usually in the deep veins of the arms, legs and pulmonary system and, on occasion, in other venous territories (e.g. cerebral veins or sinus, mesenteric, portal, hepatic, renal and/or retinal veins)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013144"
    },
    {
      "id": 18455,
      "label": "traumatic avascular necrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021660",
          "MEDGEN:1802844",
          "Orphanet:399175",
          "UMLS:C5680037",
          "icd11.foundation:822486319"
        ],
        "synonyms": [
          "traumatic AVN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018375"
    },
    {
      "id": 18456,
      "label": "secondary non-traumatic avascular necrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021661",
          "MEDGEN:1684106",
          "Orphanet:399180",
          "UMLS:C5192430"
        ],
        "synonyms": [
          "secondary non-traumatic AVN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018376"
    },
    {
      "id": 18457,
      "label": "osteonecrosis of the jaw",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021663",
          "ICD9:733.45",
          "MEDGEN:751019",
          "NCIT:C63924",
          "Orphanet:399293",
          "SCTID:441809006",
          "UMLS:C2711248"
        ],
        "synonyms": [
          "ONJ",
          "jaw osteonecrosis",
          "osteonecrosis of jaw"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An area of necrotic bone in the mandible or maxilla."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018378"
    }
  ],
  "roots": [
    {
      "id": 18453,
      "label": "avascular necrosis"
    }
  ]
}