{
  "id": 18458,
  "label": "primary avascular necrosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018379",
  "properties": {
    "xrefs": [
      "GARD:0021664",
      "MEDGEN:1842421",
      "Orphanet:399302",
      "UMLS:C5680038"
    ],
    "synonyms": [
      "primary AVN"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18453,
      "label": "avascular necrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7060
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021658",
          "MEDGEN:10200",
          "NCIT:C34841",
          "Orphanet:399164",
          "SCTID:397758007",
          "UMLS:C0027543"
        ],
        "synonyms": [
          "AVN",
          "avascular necrosis of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018373"
    }
  ],
  "children": [
    {
      "id": 13192,
      "label": "familial avascular necrosis of femoral head",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18458,
        18462
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010914",
          "MEDGEN:909851",
          "MESH:D005271",
          "NANDO:1200373",
          "NCIT:C35480",
          "OMIMPS:608805",
          "Orphanet:86820",
          "SCTID:715657008",
          "UMLS:C4275066",
          "icd11.foundation:1216860745"
        ],
        "synonyms": [
          "aseptic Necrosis of femoral head",
          "aseptic Necrosis of head of femur",
          "familial osteonecrosis of the femoral head",
          "ANFH",
          "ANFH1",
          "avascular NECROSIS of femoral head, primary",
          "avascular NECROSIS of femoral head, primary, 1",
          "avascular Necrosis of femoral head, primary, 1",
          "familial avascular necrosis of the femoral head",
          "femoral head, aseptic Necrosis of",
          "femoral head, avascular Necrosis of",
          "ischaemic Necrosis of femoral head",
          "ischemic Necrosis of femoral head",
          "osteonecrosis of femoral head",
          "primary avascular necrosis of the femoral head"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterized by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty."
      },
      "child_count": 4,
      "reference_id": "MONDO:0012126"
    },
    {
      "id": 13951,
      "label": "pseudohypoparathyroidism type 1C",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18458,
        18462,
        19473,
        19702,
        25052
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0051013",
          "GARD:0010681",
          "MEDGEN:420958",
          "MESH:C548076",
          "NANDO:1201077",
          "OMIM:612462",
          "Orphanet:79444",
          "SCTID:717792007",
          "UMLS:C2932716",
          "icd11.foundation:1401673748"
        ],
        "synonyms": [
          "pseudohypoparathyroidism Ic",
          "PHP1C",
          "Php 1C",
          "pseudohypoparathyroidism, type 1C",
          "pseudohypoparathyroidism, type IC"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare type of pseudohypoparathyroidism (PHP) characterized by resistance to parathyroid hormone (PTH) and other hormones, which manifests with hypocalcemia, hyperphosphatemia and elevated PTH levels, a constellation of clinical features collectively termed Albright's hereditary osteodystrophy (AHO), but normal activity of the stimulatory protein G (Gs alpha)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012911"
    },
    {
      "id": 18459,
      "label": "idiopathic avascular necrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18458,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021665",
          "MEDGEN:1805758",
          "Orphanet:399307",
          "UMLS:C1404767",
          "icd11.foundation:551598148"
        ],
        "synonyms": [
          "idiopathic AVN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018380"
    }
  ],
  "roots": [
    {
      "id": 18453,
      "label": "avascular necrosis"
    }
  ]
}