{
  "id": 18486,
  "label": "eosinophilic gastrointestinal disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018438",
  "properties": {
    "xrefs": [
      "GARD:0021714",
      "MEDGEN:1826142",
      "NANDO:1200454",
      "NANDO:2200807",
      "Orphanet:402029",
      "UMLS:C5680014"
    ],
    "synonyms": [
      "EGID",
      "primary eosinophilic gastrointestinal disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6756,
      "label": "intestinal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5295",
          "EFO:0009431",
          "ICD9:520-579",
          "ICD9:560-569",
          "ICD9:564",
          "ICD9:564.4",
          "ICD9:569",
          "ICD9:569.4",
          "ICD9:569.49",
          "ICD9:569.89",
          "ICD9:569.9",
          "ICD9:570-579",
          "ICD9:575",
          "MEDGEN:7130",
          "MESH:D007410",
          "NCIT:C26801",
          "SCTID:85919009",
          "UMLS:C0021831"
        ],
        "synonyms": [
          "disease of intestine",
          "disease or disorder of intestine",
          "disorder of intestine",
          "intestinal disease",
          "intestinal disorder",
          "intestine disease",
          "intestine disease or disorder",
          "disease, intestinal",
          "diseases, intestinal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the small or large intestine."
      },
      "child_count": 58,
      "reference_id": "MONDO:0005020"
    }
  ],
  "children": [
    {
      "id": 7044,
      "label": "eosinophilic esophagitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3630,
        18486
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13922",
          "EFO:0004232",
          "GARD:0027720",
          "ICD10CM:K20.0",
          "ICD9:530.13",
          "MEDGEN:83318",
          "MESH:D057765",
          "MedDRA:10064212",
          "NANDO:1200456",
          "NCIT:C27105",
          "Orphanet:73247",
          "SCTID:235599003",
          "UMLS:C0341106"
        ],
        "synonyms": [
          "EoE"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Eosinophilic esophagitis (EoE) is a chronic, allergic disease of the esophagus characterized clinically by symptoms of esophageal dysfunction (including vomiting, dysphagia, feeding disorders, food impaction and abdominal pain) which persist after treatment with proton pump inhibitors (PPIs)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005361"
    },
    {
      "id": 16742,
      "label": "eosinophilic gastroenteritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4384,
        18486
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4031",
          "GARD:0009142",
          "ICD10CM:K52.81",
          "ICD9:558.41",
          "MEDGEN:220382",
          "MedDRA:10017902",
          "NANDO:1200457",
          "NCIT:C35330",
          "NORD:1097",
          "Orphanet:2070",
          "SCTID:359804008",
          "UMLS:C1262481"
        ],
        "synonyms": [
          "EGE",
          "eosinophilic enteritis",
          "eosinophilic gastroenteritis",
          "eosinophilic gastroenterocolitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Eosinophilic gastroenteritis (EGE) is a rare benign gastrointestinal disease characterized by the presence of abnormal and nonspecific gastro-intestinal (GI) manifestations, associated with an eosinophilic infiltration of the GI tract, which can affect several segments and involve several layers within the GI wall."
      },
      "child_count": 4,
      "reference_id": "MONDO:0016129"
    },
    {
      "id": 18508,
      "label": "proton-pump inhibitor-responsive esophageal eosinophilia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18486
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021735",
          "MEDGEN:1669432",
          "Orphanet:411696",
          "UMLS:C4749332"
        ],
        "synonyms": [
          "PPI-REE",
          "PPI-responsive esophageal eosinophilia",
          "PPIRee"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a rare, gastroenterologic disease characterized by typical clinical, endoscopic and histological features of eosinophilic oesophagitis (i.e. symptomatic oesophageal dysfunction associated with eosinophil-predominant mucose infiltrate) which completely remits upon proton pump inhibitor therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018468"
    }
  ],
  "roots": [
    {
      "id": 6756,
      "label": "intestinal disorder"
    }
  ]
}