{
  "id": 18506,
  "label": "insulin autoimmune syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018465",
  "properties": {
    "xrefs": [
      "DOID:0040100",
      "GARD:0010808",
      "ICD9:279.49",
      "MEDGEN:678528",
      "Orphanet:411593",
      "SCTID:408539000",
      "UMLS:C0854359"
    ],
    "synonyms": [
      "Hirata disease",
      "insulin autoimmune hypoglycemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. Insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. When blood sugar levels get too high, insulin helps to store the sugar for future use. People affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. Insulin autoimmune syndrome most often begins during adulthood."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060005",
          "ICD9:279.49",
          "MEDGEN:575099",
          "SCTID:237822008",
          "UMLS:C0342552"
        ],
        "synonyms": [
          "endocrine system autoimmune disease",
          "endocrine system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the endocrine system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000569"
    },
    {
      "id": 7419,
      "label": "hyperinsulinemic hypoglycemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        19082
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13317",
          "EFO:0007318",
          "GARD:0021849",
          "HP:0000825",
          "MEDGEN:351247",
          "NANDO:2100143",
          "NANDO:2200399",
          "OMIMPS:256450",
          "Orphanet:443095",
          "SCTID:42681006",
          "UMLS:C1864903"
        ],
        "synonyms": [
          "hyperinsulinemia hypoglycemia",
          "hyperinsulinemic hypoglycemia (disease)",
          "nesidioblastosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the pancreas and congenital hyperinsulinism. It is due to focal hyperplasia of pancreatic islet cells budding off from the ductal structures and forming new islets of langerhans. Mutations in the islet cells involve the potassium channel gene kcnj11 or the atp-binding cassette transporter gene abcc8, both on chromosome 11."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005803"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system"
    },
    {
      "id": 7419,
      "label": "hyperinsulinemic hypoglycemia"
    }
  ]
}