{
  "id": 18508,
  "label": "proton-pump inhibitor-responsive esophageal eosinophilia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018468",
  "properties": {
    "xrefs": [
      "GARD:0021735",
      "MEDGEN:1669432",
      "Orphanet:411696",
      "UMLS:C4749332"
    ],
    "synonyms": [
      "PPI-REE",
      "PPI-responsive esophageal eosinophilia",
      "PPIRee"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a rare, gastroenterologic disease characterized by typical clinical, endoscopic and histological features of eosinophilic oesophagitis (i.e. symptomatic oesophageal dysfunction associated with eosinophil-predominant mucose infiltrate) which completely remits upon proton pump inhibitor therapy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18486,
      "label": "eosinophilic gastrointestinal disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6756
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021714",
          "MEDGEN:1826142",
          "NANDO:1200454",
          "NANDO:2200807",
          "Orphanet:402029",
          "UMLS:C5680014"
        ],
        "synonyms": [
          "EGID",
          "primary eosinophilic gastrointestinal disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0018438"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18486,
      "label": "eosinophilic gastrointestinal disease"
    }
  ]
}