{
  "id": 18510,
  "label": "renal agenesis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018470",
  "properties": {
    "xrefs": [
      "DOID:14766",
      "GARD:0009228",
      "HP:0000104",
      "HP:0008678",
      "MEDGEN:154237",
      "NANDO:2200156",
      "NCIT:C99041",
      "OMIMPS:191830",
      "Orphanet:411709",
      "SCTID:204942005",
      "UMLS:C0542519",
      "icd11.foundation:683319223"
    ],
    "synonyms": [
      "absent/small kidney",
      "absent/underdeveloped kidney",
      "renal agenesis",
      "renal agenesis (disease)",
      "renal agenesis/hypoplasia",
      "renal hypodysplasia/aplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Renal agenesis (RA) is a form of renal tract malformation characterized by the complete absence of development of one or both kidneys (unilateral RA or bilateral RA respectively), accompanied by absent ureter(s)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    },
    {
      "id": 23932,
      "label": "inherited kidney disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6948
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "genetic renal disease",
          "inherited kidney disease",
          "inherited renal disorder",
          "nephrogenetic disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the kidney or urinary system."
      },
      "child_count": 52,
      "reference_id": "MONDO:0100191"
    }
  ],
  "children": [
    {
      "id": 15322,
      "label": "renal hypodysplasia/aplasia 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024984",
          "MEDGEN:816689",
          "OMIM:615721",
          "UMLS:C3810359"
        ],
        "synonyms": [
          "FGF20 renal agenesis (disease)",
          "renal agenesis (disease) caused by mutation in FGF20",
          "renal hypodysplasia/aplasia 2",
          "renal hypodysplasia/aplasia type 2",
          "RHDA2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Any renal agenesis in which the cause of the disease is a mutation in the FGF20 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014319"
    },
    {
      "id": 16631,
      "label": "bilateral renal agenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080200",
          "GARD:0016579",
          "ICD10CM:Q60.1",
          "MEDGEN:296299",
          "NCIT:C101219",
          "NORD:1656",
          "Orphanet:1848",
          "UMLS:C1609433"
        ],
        "synonyms": [
          "Renal Agenesis, Bilateral",
          "bilateral renal aplasia",
          "renal agenesis, bilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Bilateral renal agenesis is the most profound form of renal agenesis, characterized by complete absence of kidney development, absent ureters and subsequent absence of fetal renal function resulting in Potter sequence with pulmonary hypoplasia related to oligohydramnios, which is fatal shortly after birth."
      },
      "child_count": 1,
      "reference_id": "MONDO:0015986"
    },
    {
      "id": 19426,
      "label": "renal agenesis, unilateral",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016804",
          "ICD10CM:Q60.0",
          "MEDGEN:75607",
          "MedDRA:10053624",
          "NCIT:C101220",
          "Orphanet:93100",
          "UMLS:C0266294",
          "icd11.foundation:760295498"
        ],
        "synonyms": [
          "congenital single kidney",
          "congenital solitary kidney",
          "unilateral renal agenesis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Unilateral renal agenesis (URA) is a form of renal agenesis characterized by the complete absence of development of one kidney accompanied by an absent ureter."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019636"
    },
    {
      "id": 21465,
      "label": "renal hypodysplasia/aplasia 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004791",
          "MEDGEN:301437",
          "OMIM:191830",
          "UMLS:C1619700"
        ],
        "synonyms": [
          "RHDA1",
          "renal hypodysplasia/aplasia 1",
          "Selig Benacerraf Greene syndrome",
          "hereditary renal aplasia",
          "renal adysplasia",
          "renal agenesis",
          "renal aplasia",
          "renal dysplasia, megalocystis, and sirenomelia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0024519"
    },
    {
      "id": 21466,
      "label": "renal hypodysplasia/aplasia 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025410",
          "MEDGEN:1626497",
          "OMIM:617805",
          "UMLS:C4540497"
        ],
        "synonyms": [
          "RHDA3",
          "renal hypodysplasia/aplasia 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0024520"
    },
    {
      "id": 22057,
      "label": "renal hypodysplasia/aplasia 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18510
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025644",
          "MEDGEN:1808595",
          "OMIM:619887",
          "UMLS:C5676993"
        ],
        "synonyms": [
          "RHDA4",
          "renal hypodysplasia/aplasia 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030822"
    }
  ],
  "roots": [
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    },
    {
      "id": 23932,
      "label": "inherited kidney disorder"
    }
  ]
}