{
  "id": 18530,
  "label": "malignant hyperthermia of anesthesia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018493",
  "properties": {
    "xrefs": [
      "DOID:8545",
      "GARD:0006964",
      "HP:0002047",
      "ICD9:995.86",
      "MEDGEN:9867",
      "MESH:D008305",
      "MedDRA:10020844",
      "NCIT:C84869",
      "Orphanet:423",
      "SCTID:405501007",
      "UMLS:C0024591"
    ],
    "synonyms": [
      "anaesthesia related hyperthermia",
      "hyperthermia of anaesthesia",
      "hyperthermia of anesthesia",
      "malignant hyperpyrexia",
      "malignant hyperpyrexia due to anaesthesia",
      "malignant hyperthermia",
      "malignant hyperthermia of anesthesia",
      "malignant hyperthermia syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19001,
      "label": "muscular channelopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18957,
        29384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018917",
          "MEDGEN:1842600",
          "Orphanet:71864",
          "UMLS:C5681306"
        ],
        "synonyms": [
          "channelopathy of muscle tissue",
          "muscle tissue channelopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A channelopathy that involves the muscle tissue."
      },
      "child_count": 24,
      "reference_id": "MONDO:0019119"
    },
    {
      "id": 24271,
      "label": "hereditary neuromuscular disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18957,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026275"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that is characterized by progressive muscle degeneration and weakness."
      },
      "child_count": 44,
      "reference_id": "MONDO:0100546"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19001,
      "label": "muscular channelopathy"
    },
    {
      "id": 24271,
      "label": "hereditary neuromuscular disease"
    }
  ]
}