{
  "id": 18541,
  "label": "squamous cell carcinoma of the small intestine",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018509",
  "properties": {
    "xrefs": [
      "GARD:0021764",
      "MEDGEN:313711",
      "NCIT:C43534",
      "Orphanet:423968",
      "UMLS:C1710111"
    ],
    "synonyms": [
      "small intestinal squamous cell cancer",
      "small intestinal squamous cell carcinoma",
      "small intestine squamous cell carcinoma",
      "squamous cell carcinoma of the small bowel"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the small intestine. It is composed of malignant squamous cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 7176,
      "label": "small intestine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3225,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4907",
          "EFO:0005588",
          "GARD:0024201",
          "MEDGEN:65952",
          "NCIT:C7724",
          "ONCOTREE:SIC",
          "SCTID:448664009",
          "UMLS:C0238196",
          "icd11.foundation:1484520499"
        ],
        "synonyms": [
          "cancer of small bowel",
          "cancer of the small bowel",
          "small bowel cancer",
          "small intestinal cancer",
          "small intestine cancer",
          "carcinoma of small bowel",
          "carcinoma of small intestine",
          "carcinoma of the small bowel",
          "carcinoma of the small intestine",
          "small bowel carcinoma",
          "small intestinal carcinoma",
          "small intestine cancer, NOS",
          "small intestine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the small intestine"
      },
      "child_count": 6,
      "reference_id": "MONDO:0005522"
    }
  ],
  "children": [
    {
      "id": 5407,
      "label": "ampulla of vater squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7758,
        17870,
        18541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5527",
          "GARD:0023526",
          "MEDGEN:272304",
          "NCIT:C27417",
          "UMLS:C1332251"
        ],
        "synonyms": [
          "ampulla of Vater squamous cell carcinoma",
          "hepatopancreatic ampulla squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003490"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 7176,
      "label": "small intestine carcinoma"
    }
  ]
}