{
  "id": 18551,
  "label": "carcinoma of liver and intrahepatic biliary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018531",
  "properties": {
    "xrefs": [
      "GARD:0021786",
      "MEDGEN:78921",
      "NCIT:C7927",
      "ONCOTREE:HCCIHCH",
      "Orphanet:424936",
      "UMLS:C0279000"
    ],
    "synonyms": [
      "cancer of liver",
      "cancer of liver and intrahepatic biliary tract",
      "cancer of the liver",
      "cancer of the liver and intrahepatic biliary tract",
      "carcinoma of liver",
      "hepatic cancer",
      "liver and intrahepatic bile duct cancer",
      "liver cancer",
      "liver carcinoma",
      "liver/hepatobiliary cancer",
      "carcinoma of liver and IBT",
      "liver and intrahepatic bile duct carcinoma",
      "liver and intrahepatic biliary tract cancer",
      "liver and intrahepatic biliary tract carcinoma",
      "primary liver carcinoma",
      "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 4735,
      "label": "liver cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        20310,
        21432
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3571",
          "GARD:0027613",
          "ICD9:155.0",
          "ICD9:155.2",
          "MEDGEN:87520",
          "NCIT:C34803",
          "SCTID:93870000",
          "UMLS:C0345904",
          "icd11.foundation:1605020868"
        ],
        "synonyms": [
          "cancer of liver",
          "hepatic cancer",
          "liver cancer",
          "malignant liver neoplasm",
          "malignant neoplasm of liver",
          "malignant neoplasm of liver, not specified as primary or secondary",
          "malignant neoplasm of liver, primary",
          "malignant tumour of liver",
          "primary liver cancer",
          "primary malignant liver neoplasm",
          "primary malignant neoplasm of liver",
          "primary cancer of liver",
          "primary tumor of the liver",
          "primary tumour of the liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002691"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    }
  ],
  "children": [
    {
      "id": 6493,
      "label": "liver carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9132",
          "GARD:0024097",
          "ICD10CM:D01.5",
          "ICD9:230.8",
          "MEDGEN:577201",
          "SCTID:92644006",
          "UMLS:C0345908",
          "icd11.foundation:1380265780"
        ],
        "synonyms": [
          "carcinoma in situ of liver",
          "carcinoma in situ of liver, gallbladder and bile ducts",
          "liver in situ carcinoma",
          "stage 0 liver carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma in situ involving a liver."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004715"
    },
    {
      "id": 7152,
      "label": "bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5049,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4897",
          "EFO:0005540",
          "GARD:0024194",
          "MEDGEN:152840",
          "NCIT:C27814",
          "UMLS:C0740277"
        ],
        "synonyms": [
          "bile duct cancer",
          "bile duct cancer (including cholangiocarcinoma)",
          "bile duct carcinoma",
          "carcinoma of bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the bile duct"
      },
      "child_count": 8,
      "reference_id": "MONDO:0005496"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:684",
          "DOID:686",
          "EFO:0000182",
          "GARD:0016773",
          "ICD10CM:C22.0",
          "ICDO:8170/3",
          "MEDGEN:389187",
          "MESH:D006528",
          "MedDRA:10049010",
          "NANDO:2200047",
          "NCIT:C3099",
          "NORD:1907",
          "OMIM:114550",
          "ONCOTREE:HCC",
          "Orphanet:88673",
          "UMLS:C2239176",
          "icd11.foundation:1294035808"
        ],
        "synonyms": [
          "HCC",
          "cancer, hepatocellular",
          "carcinoma of liver",
          "carcinoma of liver cells",
          "carcinoma of the liver cells",
          "carcinoma, hepatocellular, malignant",
          "hepatoblastoma, somatic",
          "hepatocellular adenocarcinoma",
          "hepatocellular cancer",
          "hepatocellular cancer, somatic",
          "hepatocellular carcinoma",
          "hepatocellular carcinoma, childhood type, somatic",
          "hepatocellular carcinoma, somatic",
          "hepatoma",
          "liver carcinoma",
          "liver cell cancer (hepatocellular carcinoma)",
          "liver cell carcinoma",
          "primary carcinoma of liver cells",
          "primary carcinoma of the liver cells",
          "adult hepatoma",
          "adult primary hepatocellular carcinoma",
          "hepatoblastoma",
          "hepatoblastoma caused by somatic mutation",
          "liver and intrahepatic bile duct carcinoma",
          "liver cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0007256"
    },
    {
      "id": 16046,
      "label": "liver neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        18551,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019760",
          "MEDGEN:474664",
          "NCIT:C96787",
          "Orphanet:100085",
          "SCTID:716652006",
          "UMLS:C3273031"
        ],
        "synonyms": [
          "HNEC",
          "PHNEC",
          "hepatic neuroendocrine carcinoma",
          "liver neuroendocrine cancer",
          "liver neuroendocrine carcinoma",
          "neuroendocrine carcinoma of liver",
          "primary hepatic neuroendocrine carcinoma",
          "primary liver neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An extremely rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015072"
    },
    {
      "id": 18552,
      "label": "undifferentiated carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7257,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021788",
          "MEDGEN:1656437",
          "Orphanet:424970",
          "UMLS:C4749401"
        ],
        "synonyms": [
          "undifferentiated carcinoma of liver and IBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Undifferentiated carcinoma of liver and intrahepatic biliary tract is an extremely rare epithelial tumor of the liver and biliary tract which presents heterogenous histological findings and not yet fully defined clinicopathological characteristics. Patients usually present with nonspecific signs and symptoms, such as abdominal pain, nausea, vomiting, anorexia, weight loss and/or jaundice. Invasive growth, high metastatic potential and a rapid clinical course are typically associated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018533"
    },
    {
      "id": 18553,
      "label": "squamous cell carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021789",
          "MEDGEN:1668494",
          "Orphanet:424975",
          "UMLS:C4749400"
        ],
        "synonyms": [
          "squamous cell carcinoma of liver and IBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Squamous cell carcinoma of liver and intrahepatic biliary tract is an extremely rare, primary, malignant liver and biliray tract epithelial tumor originating in the intrahepatic bile duct epithelium histologically characterized by the presence of keratinization and/or intracellular bridges. Patients typically present abdominal pain in the right upper quadrant, jaundice, nausea, vomiting, anorexia, weight loss, fever and/or dyspepsia."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018534"
    },
    {
      "id": 18554,
      "label": "biliary cystadenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5050,
        7240,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021790",
          "MEDGEN:473526",
          "Orphanet:424982",
          "UMLS:C2064409"
        ],
        "synonyms": [
          "intrahepatic bile duct cystadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A cystadenocarcinoma that involves the biliary tree."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018535"
    }
  ],
  "roots": [
    {
      "id": 4735,
      "label": "liver cancer"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    }
  ]
}